[Tetrapeptide stimulates functional activity of the pancreatic cells in aging].

Khavinson VKh, Sevost'ianova NN, Durnova AO, Lin'kova NS, Tarnovskaia SI, Dudkov AV, Kvetnaia TV

Advances in gerontology = Uspekhi gerontologii1 Jan 2012Cited by 2 (Europe PMC)

PMID23734516DOI10.1134/s2079057013030053PepBankPUB-23734516

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen increased MMP2 expression.
In plain wordsIn cells, Pancragen increased MMP2 expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseMMP2 expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451601
02LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen increased MMP9 expression.
In plain wordsIn cells, Pancragen increased MMP9 expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseMMP9 expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451602
03LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen increased serotonin expression.
In plain wordsIn cells, Pancragen increased serotonin expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseSerotonin expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451603
04LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen increased CD79alpha expression.
In plain wordsIn cells, Pancragen increased CD79alpha expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseCD79alpha expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451604
05LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen increased Mcl1 expression.
In plain wordsIn cells, Pancragen increased Mcl1 expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseMcl1 expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451605
06LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen increased PCNA expression.
In plain wordsIn cells, Pancragen increased PCNA expression.
Peptide
Pancragen (KEDW)
Outcome
IncreasePCNA expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451606
07LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen increased Ki67 expression.
In plain wordsIn cells, Pancragen increased Ki67 expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseKi67 expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451607
08LabIn vitro (cells)Mechanism
In aged human pancreatic cell cultures, Pancragen decreased p53 expression.
In plain wordsIn cells, Pancragen decreased p53 expression.
Peptide
Pancragen (KEDW)
Outcome
Decreasep53 expression
Study
humann: not reported in source
aged pancreatic cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated.
Report a problemFND-2373451608

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 17:05 UTC
Study results updated
Version 1
21 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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