In vitro, ceftaroline enhanced daptomycin binding to the cell membrane and sensitized E. faecalis to killing by LL‑37.
In plain wordsIn lab tests, the antibiotic ceftaroline made E. faecalis more easily killed by LL‑37.
- Peptide
- LL-37
- Outcome
- IncreaseSensitization of E. faecalis to LL-37 killing by ceftaroline
- Study
Enterococcus faecalisn: not reported in source
- Outcome group
- Infection and antimicrobial activity · Infection
Source sentences
Mechanistically, ceftaroline enhanced binding of daptomycin to the cell membrane and sensitized E. faecalis to killing by human cathelicidin LL-37, a cationic innate host defense peptide.
1 context sentence(design, population, supporting numbers)
This combination demonstrated excellent synergy in vitro.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.