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Study · Randomized controlled trial · 2013

5 results

The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects.

Wang Y, Wang M, Xiao XS, Pan P, Li P, Huo J

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology22 Apr 2013Cited by 5 (Europe PMC)

PMID23607739 (opens in a new tab)DOI10.3109/14764172.2012.759234 (opens in a new tab)PepBankPUB-23607739
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In Chinese subjects, total anti-wrinkle efficiency with Argireline was 48.9%.

    In plain wordsIn Chinese subjects, Argireline had a reported anti-wrinkle efficiency of 48.9%.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Not applicableAnti-wrinkle efficiency
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · 4 weeksAs given in this study (human).

    Measurements

    Anti-wrinkle efficiency
    48.9%
    Argireline group

    Source sentences

    Summary
    In humans, the total anti wrinkle efficiency in the Argireline group was 48.9%, the depth of the wrinkles was notably reduced(P<0.01).
    2 context sentences
    Summary · context
    The study was comprised of two parts: i) Clinical study: A total of 60 subjects received a single treatment in a 3:1 randomization ratio of Argireline: placebo.
    Summary · context
    Argireline or placebo was applied to their periorbital wrinkles twice daily for 4 weeks, evaluations were made for the improvements in wrinkles. ii) Animal study: Argireline was applied to the aged mice twice daily for 6 weeks and the histopathological changes of skin tissue were evaluated.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In Chinese subjects, Argireline reduced wrinkle depth.

    In plain wordsIn Chinese subjects, Argireline reduced wrinkle depth.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    DecreaseWrinkle depth
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    In humans, the total anti wrinkle efficiency in the Argireline group was 48.9%, the depth of the wrinkles was notably reduced(P<0.01).
    2 context sentences
    Summary · context
    The study was comprised of two parts: i) Clinical study: A total of 60 subjects received a single treatment in a 3:1 randomization ratio of Argireline: placebo.
    Summary · context
    Argireline or placebo was applied to their periorbital wrinkles twice daily for 4 weeks, evaluations were made for the improvements in wrinkles. ii) Animal study: Argireline was applied to the aged mice twice daily for 6 weeks and the histopathological changes of skin tissue were evaluated.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, Argireline improved skin tissue morphology.

    In plain wordsIn mice with induced aging, Argireline improved skin tissue structure.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseSkin morphology
    Study

    mousen: not reported in source

    D-galactose-induced aged mice
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the aged mice, there was improvements in the morphology of skin tissue, the amount of typeⅠcollagen fibers increased(P<0.01) while type Ⅲ collagen fibers decreased (P<0.05).
    2 context sentences
    Summary · context
    The study was comprised of two parts: i) Clinical study: A total of 60 subjects received a single treatment in a 3:1 randomization ratio of Argireline: placebo.
    Summary · context
    Argireline or placebo was applied to their periorbital wrinkles twice daily for 4 weeks, evaluations were made for the improvements in wrinkles. ii) Animal study: Argireline was applied to the aged mice twice daily for 6 weeks and the histopathological changes of skin tissue were evaluated.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, Argireline increased type I collagen fibers.

    In plain wordsIn mice with induced aging, Argireline increased type I collagen fibers.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseType I collagen fibers
    Study

    mousen: not reported in source

    D-galactose-induced aged mice
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the aged mice, there was improvements in the morphology of skin tissue, the amount of typeⅠcollagen fibers increased(P<0.01) while type Ⅲ collagen fibers decreased (P<0.05).
    2 context sentences
    Summary · context
    The study was comprised of two parts: i) Clinical study: A total of 60 subjects received a single treatment in a 3:1 randomization ratio of Argireline: placebo.
    Summary · context
    Argireline or placebo was applied to their periorbital wrinkles twice daily for 4 weeks, evaluations were made for the improvements in wrinkles. ii) Animal study: Argireline was applied to the aged mice twice daily for 6 weeks and the histopathological changes of skin tissue were evaluated.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, Argireline decreased type III collagen fibers.

    In plain wordsIn mice with induced aging, Argireline decreased type III collagen fibers.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    DecreaseType III collagen fibers
    Study

    mousen: not reported in source

    D-galactose-induced aged mice
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the aged mice, there was improvements in the morphology of skin tissue, the amount of typeⅠcollagen fibers increased(P<0.01) while type Ⅲ collagen fibers decreased (P<0.05).
    2 context sentences
    Summary · context
    The study was comprised of two parts: i) Clinical study: A total of 60 subjects received a single treatment in a 3:1 randomization ratio of Argireline: placebo.
    Summary · context
    Argireline or placebo was applied to their periorbital wrinkles twice daily for 4 weeks, evaluations were made for the improvements in wrinkles. ii) Animal study: Argireline was applied to the aged mice twice daily for 6 weeks and the histopathological changes of skin tissue were evaluated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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