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Study · Animal study (in vivo) · rat · 2013

6 results

The effect of PTH(1-34) on fracture healing during different loading conditions.

Ellegaard M, Kringelbach T, Syberg S, Petersen S, Beck Jensen JE, Brüel A, Jørgensen NR, Schwarz P

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Oct 2013Cited by 34 (Europe PMC)

PMID23585311 (opens in a new tab)DOI10.1002/jbmr.1957 (opens in a new tab)PepBankPUB-23585311
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH did not affect callus area under normal or reduced loading compared with vehicle.

    In plain wordsIn rats, PTH did not change fracture callus area compared with vehicle under normal or reduced loading.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCallus area
    Study

    ratn: not reported in source

    ovariectomized rats with tibial fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 µg/kg/day · injection · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    We found that unloading reduced callus area significantly, whereas no effects of PTH(1-34) on callus area were seen in neither normally nor unloaded animals.
    3 context sentences
    Summary · context
    For this purpose, we used female, 25-week-old ovariectomized rats.
    Summary · context
    Animals were subjected to closed midshaft fracture of the right tibia 10 weeks after ovariectomy.
    Summary · context
    For the following 8 weeks, half of the animals in each group received injections of hPTH(1-34) (20 µg/kg/day) and the other half received vehicle treatment.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with tibial fracture, PTH increased callus BMD compared with vehicle.

    In plain wordsIn rats, PTH increased fracture callus bone density compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus BMD
    Study

    ratn: not reported in source

    ovariectomized rats with tibial fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 µg/kg/day · injection · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    PTH(1-34) increased callus bone mineral density (BMD) and bone mineral content (BMC) significantly, whereas unloading decreased callus BMD and BMC significantly.
    3 context sentences
    Summary · context
    For this purpose, we used female, 25-week-old ovariectomized rats.
    Summary · context
    Animals were subjected to closed midshaft fracture of the right tibia 10 weeks after ovariectomy.
    Summary · context
    For the following 8 weeks, half of the animals in each group received injections of hPTH(1-34) (20 µg/kg/day) and the other half received vehicle treatment.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with tibial fracture, PTH increased callus bone mineral content compared with vehicle.

    In plain wordsIn rats, PTH increased fracture callus mineral content compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus bone mineral content
    Study

    ratn: not reported in source

    ovariectomized rats with tibial fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 µg/kg/day · injection · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    PTH(1-34) increased callus bone mineral density (BMD) and bone mineral content (BMC) significantly, whereas unloading decreased callus BMD and BMC significantly.
    3 context sentences
    Summary · context
    For this purpose, we used female, 25-week-old ovariectomized rats.
    Summary · context
    Animals were subjected to closed midshaft fracture of the right tibia 10 weeks after ovariectomy.
    Summary · context
    For the following 8 weeks, half of the animals in each group received injections of hPTH(1-34) (20 µg/kg/day) and the other half received vehicle treatment.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH increased callus bone volume compared with vehicle under normal and reduced loading.

    In plain wordsIn rats, PTH increased fracture callus bone volume compared with vehicle under normal and reduced loading.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus bone volume
    Study

    ratn: not reported in source

    ovariectomized rats with tibial fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 µg/kg/day · injection · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    PTH(1-34) treatment increased bone volume of the callus in both unloaded and control animals.
    3 context sentences
    Summary · context
    For this purpose, we used female, 25-week-old ovariectomized rats.
    Summary · context
    Animals were subjected to closed midshaft fracture of the right tibia 10 weeks after ovariectomy.
    Summary · context
    For the following 8 weeks, half of the animals in each group received injections of hPTH(1-34) (20 µg/kg/day) and the other half received vehicle treatment.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH increased fracture ultimate force by 63% under normal and reduced loading, without detectable interaction.

    In plain wordsIn rats, PTH increased fracture strength compared with vehicle under normal and reduced loading.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFracture ultimate force
    Study

    ratn: not reported in source

    ovariectomized rats with tibial fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 µg/kg/day · injection · 8 weeksAs given in this study (rat).

    Measurements

    Ultimate force increase
    63%
    control and unloaded animals

    Source sentences

    Summary
    PTH(1-34) treatment increased ultimate force of the fracture by 63% in both control and unloaded animals and no interaction of the two interventions could be detected.
    3 context sentences
    Summary · context
    For this purpose, we used female, 25-week-old ovariectomized rats.
    Summary · context
    Animals were subjected to closed midshaft fracture of the right tibia 10 weeks after ovariectomy.
    Summary · context
    For the following 8 weeks, half of the animals in each group received injections of hPTH(1-34) (20 µg/kg/day) and the other half received vehicle treatment.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH stimulated intact bone formation under normal and reduced loading compared with vehicle.

    In plain wordsIn rats, PTH increased intact bone formation compared with vehicle under normal and reduced loading.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseIntact bone formation
    Study

    ratn: not reported in source

    ovariectomized rats with tibial fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 µg/kg/day · injection · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    PTH(1-34) was able to stimulate bone formation in normally loaded as well as unloaded intact bone.
    3 context sentences
    Summary · context
    For this purpose, we used female, 25-week-old ovariectomized rats.
    Summary · context
    Animals were subjected to closed midshaft fracture of the right tibia 10 weeks after ovariectomy.
    Summary · context
    For the following 8 weeks, half of the animals in each group received injections of hPTH(1-34) (20 µg/kg/day) and the other half received vehicle treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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