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Study · Animal study (in vivo) · rat · 2013

15 results

Improvement in functional recovery with administration of Cerebrolysin after experimental closed head injury.

Zhang Y, Chopp M, Meng Y, Zhang ZG, Doppler E, Mahmood A, Xiong Y

Journal of neurosurgery12 Apr 2013Cited by 37 (Europe PMC)

PMID23581594 (opens in a new tab)DOI10.3171/2013.3.jns122061 (opens in a new tab)PepBankPUB-23581594
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with closed head injury, Cerebrolysin improved adhesive removal test performance at 14 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin improved adhesive removal test performance at 14 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableAdhesive removal test at 14 days
    Study

    ratn = 20

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    At 14 days post-CHI, the Cerebrolysin treatment group exhibited significant improvements in functional outcomes (the adhesive removal, mNSS, foot-fault, and MWM tests)
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with closed head injury, Cerebrolysin improved modified neurological severity scores at 14 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin improved neurological severity scores at 14 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableModified neurological severity score at 14 days
    Study

    ratn = 20

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    At 14 days post-CHI, the Cerebrolysin treatment group exhibited significant improvements in functional outcomes (the adhesive removal, mNSS, foot-fault, and MWM tests)
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with closed head injury, Cerebrolysin improved foot-fault test performance at 14 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin improved foot-fault test performance at 14 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableFoot-fault test at 14 days
    Study

    ratn = 20

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    At 14 days post-CHI, the Cerebrolysin treatment group exhibited significant improvements in functional outcomes (the adhesive removal, mNSS, foot-fault, and MWM tests)
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with closed head injury, Cerebrolysin improved Morris water maze performance at 14 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin improved water maze performance at 14 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableMorris water maze at 14 days
    Study

    ratn = 20

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    At 14 days post-CHI, the Cerebrolysin treatment group exhibited significant improvements in functional outcomes (the adhesive removal, mNSS, foot-fault, and MWM tests)
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, Cerebrolysin increased dentate gyrus neurons at 14 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased dentate gyrus neurons at 14 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDentate gyrus neurons at 14 days
    Study

    ratn = 20

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    and significantly more neurons and neuroblasts were present in the dentate gyrus (DG) (p < 0.05) compared with the saline-treated group (p < 0.05).
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, Cerebrolysin increased dentate gyrus neuroblasts at 14 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased dentate gyrus immature nerve cells at 14 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDentate gyrus neuroblasts at 14 days
    Study

    ratn = 20

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    and significantly more neurons and neuroblasts were present in the dentate gyrus (DG) (p < 0.05) compared with the saline-treated group (p < 0.05).
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, Cerebrolysin increased neurons in the hippocampal CA3 region compared with saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased CA3 neurons compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCA3 neuronal counts
    Study

    ratn = 20

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin is neuroprotective for CHI (increased neurons in the dentate gyrus and the CA3 regions of the hippocampus and increased neuroblasts in the dentate gyrus) and may preserve axonal integrity in the striatum (significantly increased percentage of pNF-H-positive tissue in the striatum).
    2 context sentences
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
    Summary · context
    Animals were killed on Day 14 (n = 20) after injury, and their brains were removed and processed for measurement of neuronal cells, axonal damage, apoptosis, and neuroblasts.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, Cerebrolysin increased cortical FITC-dextran perfused vessels at 2 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased dye-perfused cortical blood vessels at 2 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCortical FITC-dextran perfused vessels at 2 days
    Study

    ratn = 16

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    a significant increase in the percentage of FITC-dextran perfused vessels in the brain cortex (p < 0.05)
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, Cerebrolysin increased VEGF-positive cells at 2 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased VEGF-positive cells at 2 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseVEGF-positive cells at 2 days
    Study

    ratn = 16

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    a significant increase in the number of VEGF-positive cells (p < 0.05)
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, Cerebrolysin reduced MMP-9 staining area at 2 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin reduced MMP-9 staining area at 2 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMMP-9 staining area at 2 days
    Study

    ratn = 16

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    a significant reduction in the MMP-9 staining area (p < 0.05) compared with the saline-treated group.
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, hippocampal MMP-9 mRNA did not differ between Cerebrolysin and saline at 48 hours.

    In plain wordsIn rats with head injury, hippocampal MMP-9 gene activity did not differ between Cerebrolysin and saline at 48 hours.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeHippocampal MMP-9 mRNA at 48 hours
    Study

    ratn = 8

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    There was no significant difference in mRNA levels of MMP-9 and VEGF in the hippocampus and cortex 48 hours postinjury between Cerebrolysin- and saline-treated rats that sustained CHI.
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, cortical MMP-9 mRNA did not differ between Cerebrolysin and saline at 48 hours.

    In plain wordsIn rats with head injury, cortical MMP-9 gene activity did not differ between Cerebrolysin and saline at 48 hours.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeCortical MMP-9 mRNA at 48 hours
    Study

    ratn = 8

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    There was no significant difference in mRNA levels of MMP-9 and VEGF in the hippocampus and cortex 48 hours postinjury between Cerebrolysin- and saline-treated rats that sustained CHI.
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  13. 13AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, hippocampal VEGF mRNA did not differ between Cerebrolysin and saline at 48 hours.

    In plain wordsIn rats with head injury, hippocampal VEGF gene activity did not differ between Cerebrolysin and saline at 48 hours.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeHippocampal VEGF mRNA at 48 hours
    Study

    ratn = 8

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    There was no significant difference in mRNA levels of MMP-9 and VEGF in the hippocampus and cortex 48 hours postinjury between Cerebrolysin- and saline-treated rats that sustained CHI.
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  14. 14AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, cortical VEGF mRNA did not differ between Cerebrolysin and saline at 48 hours.

    In plain wordsIn rats with head injury, cortical VEGF gene activity did not differ between Cerebrolysin and saline at 48 hours.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeCortical VEGF mRNA at 48 hours
    Study

    ratn = 8

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    There was no significant difference in mRNA levels of MMP-9 and VEGF in the hippocampus and cortex 48 hours postinjury between Cerebrolysin- and saline-treated rats that sustained CHI.
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).
  15. 15AnimalAnimal study (in vivo)Mechanism

    In rats with closed head injury, Cerebrolysin increased striatal pNF-H-positive staining area at 2 days versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased striatal pNF-H staining area at 2 days compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseStriatal pNF-H-positive area at 2 days
    Study

    ratn: not reported in source

    Adult male Wistar rats with closed head injury
    Comparator
    Saline-treated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg once daily · intraperitoneal injection · 2 daysAs given in this study (rat).

    Source sentences

    Summary
    At 2 days post-CHI, the Cerebrolysin group exhibited a significantly higher percentage of phosphorylated neurofilament H (pNF-H)-positive staining area in the striatum (p < 0.05)
    1 context sentence
    Summary · context
    Closed head injured rats received intraperitoneal injection of saline (n = 30) or Cerebrolysin (2.5 ml/kg, n = 30) starting 1 hour postinjury and administered once daily until they were killed (2 or 14 days after CHI).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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