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Study · Not a test of the peptide alone · 2013

2 results

Construction, expression, and characterization of thymosin alpha 1 tandem repeats in Escherichia coli.

Xue XC, Xue XC, Yan Z, Li WN, Li M, Qin X, Zhang C, Hao Q, Wang ZL, Zhao N, Zhang W, Zhang YQ

BioMed research international28 Feb 2013Cited by 5 (Europe PMC)

PMID23555093 (opens in a new tab)PMCIDPMC3600210 (opens in a new tab)DOI10.1155/2013/720285 (opens in a new tab)PepBankPUB-23555093
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Summary

Thymosin alpha 1 (T α 1), which is composed of 28 amino acids, has been commercialized worldwide for its immune-modulatory and antitumor effects. T α 1 can stimulate T cell proliferation and differentiation from bone marrow stem cells, augment cell-mediated immune responses, and regulate homeostasis of immune system. In this study, we developed a novel strategy to produce T α 1 concatemer (T α 1③) in Escherichia coli and compared its activity with chemically synthesized T α 1. Results showed that T α 1③ can more effectively stimulate T cell proliferation and significantly upregulate IL-2 receptor expression. We concluded that the expression system for T α 1 concatemer was constructed successfully, which could serve as an efficient tool for the production of large quantities of the active protein.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In cell assays, the recombinant thymosin α1 concatemer stimulated T cell proliferation more effectively than chemically synthesized thymosin α1.

    In plain wordsIn lab tests, the repeated-sequence version of thymosin α1 stimulated T cell growth more than synthetic thymosin α1.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT cell proliferation
    Study

    n: not reported in source

    Comparator
    Chemically synthesized thymosin α1
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Results showed that T α 1③ can more effectively stimulate T cell proliferation and significantly upregulate IL-2 receptor expression.
    1 context sentence
    Summary · context
    In this study, we developed a novel strategy to produce T α 1 concatemer (T α 1③) in Escherichia coli and compared its activity with chemically synthesized T α 1.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In cell assays, the recombinant thymosin α1 concatemer significantly upregulated IL-2 receptor expression.

    In plain wordsIn lab tests, the repeated-sequence version of thymosin α1 increased IL-2 receptor levels on cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIL-2 receptor expression
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    significantly upregulate IL-2 receptor expression.
    1 context sentence
    Summary · context
    In this study, we developed a novel strategy to produce T α 1 concatemer (T α 1③) in Escherichia coli and compared its activity with chemically synthesized T α 1.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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