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Study · Measured the body's own peptide · 2013

4 results

Antimicrobial peptides and proinflammatory cytokines in periprosthetic joint infection.

Gollwitzer H, Dombrowski Y, Prodinger PM, Peric M, Summer B, Hapfelmeier A, Saldamli B, Pankow F, von Eisenhart-Rothe R, Imhoff AB, Schauber J, Thomas P, Burgkart R, Banke IJ

The Journal of bone and joint surgery. American volume1 Apr 2013Cited by 127 (Europe PMC)

PMID23553300 (opens in a new tab)DOI10.2106/jbjs.l.00205 (opens in a new tab)PepBankPUB-23553300
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with total hip or knee replacements, LL‑37 was significantly higher in joint aspirates from patients with periprosthetic joint infection than from patients with aseptic loosening, with an AUC of 0.875.

    In plain wordsIn people with joint replacements, the body's own LL‑37 was higher in joint fluid with infection than with aseptic loosening.

    Peptide
    LL-37
    Outcome
    IncreaseLL-37 in joint aspirates (periprosthetic joint infection versus aseptic loosening)
    Study

    n = 35

    Comparator
    Patients with aseptic loosening
    Outcome group
    Inflammation markers · Infection

    Measurements

    AUC
    0.875 AUC
    LL-37 in joint aspirate

    Source sentences

    Summary
    The antimicrobial peptides HBD-3 and LL-37 were significantly elevated in joint aspirates from patients with periprosthetic joint infection compared with patients with aseptic loosening, and the area under the curve (AUC) in a receiver operating characteristic curve analysis was equal to 0.745 and 0.875, respectively.
    1 context sentence
    Summary · context
    Fifteen consecutive patients with staphylococcal periprosthetic joint infections and twenty control patients with aseptic loosening of total hip and knee replacements were included in this prospective, single-center, controlled clinical trial.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with total hip or knee replacements, the combination of LL‑37 with IL-4 in synovial fluid improved diagnostic accuracy for periprosthetic joint infection, with an AUC of 0.916.

    In plain wordsIn people with joint replacements, the body's own LL‑37 together with IL-4 in joint fluid detected joint infection more accurately.

    Peptide
    LL-37
    Outcome
    IncreaseDiagnostic accuracy of LL-37 combined with IL-4 in synovial fluid
    Study

    n = 35

    Comparator
    LL-37 alone
    Outcome group
    Inflammation markers · Infection

    Measurements

    AUC
    0.916 AUC
    LL-37 and IL-4 in synovial fluid

    Source sentences

    Summary
    Logistic regression analysis indicated that the combination of an antimicrobial peptide with another synovial fluid biomarker improved diagnostic accuracy; the AUC value was 0.916 for LL-37 and IL-4, 0.895 for LL-37 and IL-6, 0.972 for HBD-3 and IL-4, and 0.849 for HBD-3 and IL-6.
    1 context sentence
    Summary · context
    Fifteen consecutive patients with staphylococcal periprosthetic joint infections and twenty control patients with aseptic loosening of total hip and knee replacements were included in this prospective, single-center, controlled clinical trial.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with total hip or knee replacements, the combination of LL‑37 with IL-6 in synovial fluid improved diagnostic accuracy for periprosthetic joint infection, with an AUC of 0.895.

    In plain wordsIn people with joint replacements, the body's own LL‑37 together with IL-6 in joint fluid detected joint infection more accurately.

    Peptide
    LL-37
    Outcome
    IncreaseDiagnostic accuracy of LL-37 combined with IL-6 in synovial fluid
    Study

    n = 35

    Comparator
    LL-37 alone
    Outcome group
    Inflammation markers · Infection

    Measurements

    AUC
    0.895 AUC
    LL-37 and IL-6 in synovial fluid

    Source sentences

    Summary
    Logistic regression analysis indicated that the combination of an antimicrobial peptide with another synovial fluid biomarker improved diagnostic accuracy; the AUC value was 0.916 for LL-37 and IL-4, 0.895 for LL-37 and IL-6, 0.972 for HBD-3 and IL-4, and 0.849 for HBD-3 and IL-6.
    1 context sentence
    Summary · context
    Fifteen consecutive patients with staphylococcal periprosthetic joint infections and twenty control patients with aseptic loosening of total hip and knee replacements were included in this prospective, single-center, controlled clinical trial.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In patients with total hip or knee replacements, serum LL‑37 did not show a significant systemic increase in association with infection.

    In plain wordsIn people with joint replacements, the body's own LL‑37 in blood was not clearly higher with joint infection.

    Peptide
    LL-37
    Outcome
    No significant changeSerum LL-37 in periprosthetic joint infection
    Study

    n = 35

    Comparator
    Patients with aseptic loosening
    Outcome group
    Inflammation markers · Infection

    Source sentences

    Summary
    In contrast, the only antimicrobial peptides and cytokines in serum that showed a significant systemic increase in association with infection were HBD-2, IL-4, and IL-6 (all of which had an AUC value of <0.75).
    2 context sentences
    Summary · context
    Expression of the antimicrobial peptides human β-defensin-2 (HBD-2), human β-defensin-3 (HBD-3), and cathelicidin LL-37 (LL-37) was determined by ELISA (enzyme-linked immunosorbent assay) in serum and joint aspirates.
    Summary · context
    Fifteen consecutive patients with staphylococcal periprosthetic joint infections and twenty control patients with aseptic loosening of total hip and knee replacements were included in this prospective, single-center, controlled clinical trial.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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