Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.

Kaminetsky J, Werner M, Fontenot G, Wiehle RD

The journal of sexual medicine26 Mar 2013Cited by 52 (Europe PMC)

PMID23530575DOI10.1111/jsm.12116PepBankPUB-23530575

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialEfficacy outcome
In hypogonadal men, enclomiphene increased sperm counts in seven of seven men at three months.
In plain wordsIn hypogonadal men, sperm counts rose in seven of seven men after three months of enclomiphene.
Peptide
Enclomiphene
Outcome
IncreaseSperm count responders at three months
Study
n = 7
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · oral · 3 monthsAs given in this study (human).
Measurements
Men with elevated sperm count
7 men (of 7)
enclomiphene citrate, 3 months
Source sentences
Summary
Enclomiphene citrate elevated sperm counts in seven out of seven men at 3 months and six out of six men at 6 months with sperm concentrations in the 75-334 × 10(6) /mL range.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
Report a problemFND-2353057506
02HumanRandomized controlled trialEfficacy outcome
In hypogonadal men, enclomiphene increased sperm counts in six of six men at six months.
In plain wordsIn hypogonadal men, sperm counts rose in six of six men after six months of enclomiphene.
Peptide
Enclomiphene
Outcome
IncreaseSperm count responders at six months
Study
n = 6
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · oral · 6 monthsAs given in this study (human).
Measurements
Men with elevated sperm count
6 men (of 6)
enclomiphene citrate, 6 months
Sperm concentration
75 to 334 × 10(6)/mL
enclomiphene recipients
Source sentences
Summary
Enclomiphene citrate elevated sperm counts in seven out of seven men at 3 months and six out of six men at 6 months with sperm concentrations in the 75-334 × 10(6) /mL range.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
Report a problemFND-2353057507
03HumanRandomized controlled trialEfficacy outcome
In hypogonadal men, mean testosterone was 525 ± 256 pg/dL after six months of enclomiphene.
In plain wordsIn hypogonadal men, testosterone averaged 525 ± 256 pg/dL after six months of enclomiphene.
Peptide
Enclomiphene
Outcome
Not applicableTotal testosterone at six months
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · oral · 6 monthsAs given in this study (human).
Measurements
Total testosterone
525 pg/dL
enclomiphene at 6 months
Reported uncertainty
256 pg/dL
type not specified; enclomiphene at 6 months
Source sentences
Summary
At 6 months, TT levels were 545 ± 268 and 525 ± 256 pg/dL for groups receiving the gel and enclomiphene citrate, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
Report a problemFND-2353057502
04HumanRandomized controlled trialEfficacy outcome
In hypogonadal men, LH increased only in the enclomiphene group, compared with testosterone gel.
In plain wordsIn hypogonadal men, LH rose only with enclomiphene, compared with testosterone gel.
Peptide
Enclomiphene
Outcome
IncreaseLH
Study
n: not reported in source
Comparator
Testosterone gel
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · oralAs given in this study (human).
Source sentences
Summary
Only men in the enclomiphene citrate group demonstrated increased LH and FSH.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
Report a problemFND-2353057503
05HumanRandomized controlled trialEfficacy outcome
In hypogonadal men, FSH increased only in the enclomiphene group, compared with testosterone gel.
In plain wordsIn hypogonadal men, FSH rose only with enclomiphene, compared with testosterone gel.
Peptide
Enclomiphene
Outcome
IncreaseFSH
Study
n: not reported in source
Comparator
Testosterone gel
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · oralAs given in this study (human).
Source sentences
Summary
Only men in the enclomiphene citrate group demonstrated increased LH and FSH.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
Report a problemFND-2353057504
06HumanRandomized controlled trialEfficacy outcome
In hypogonadal men, only enclomiphene was associated with elevated sperm counts at follow-up, compared with testosterone gel.
In plain wordsIn hypogonadal men, sperm counts remained elevated only after enclomiphene, compared with testosterone gel.
Peptide
Enclomiphene
Outcome
IncreaseSperm counts at follow-up
Study
n: not reported in source
Comparator
Testosterone gel
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · oralAs given in this study (human).
Source sentences
Summary
At follow-up, only enclomiphene citrate treatment was associated with elevated sperm counts.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
Report a problemFND-2353057508

Studies that did not test the peptide alone2

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

07HumanNot a test of Enclomiphene aloneRandomized controlled trialEfficacy outcome
In men with secondary hypogonadism previously treated with topical testosterone, testosterone rose significantly after 3 months in men receiving enclomiphene citrate and in men receiving testosterone gel, and the rise was sustained for 3 months.
In plain wordsIn hypogonadal men, testosterone rose after three months in both the enclomiphene and the testosterone gel groups and stayed elevated for three months.
Peptide
Enclomiphene
Outcome
IncreaseTestosterone rise at three months
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
After 3 months, there was a significant rise in men receiving enclomiphene citrate and gel that was sustained for 3 months.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-2353057501
08HumanNot a test of Enclomiphene aloneRandomized controlled trialEfficacy outcome
In hypogonadal men, testosterone returned to pretreatment values one month after treatment cessation, without an arm-specific result.
In plain wordsIn hypogonadal men, testosterone returned to pretreatment values one month after treatment stopped. The abstract did not separate treatment arms.
Peptide
Enclomiphene
Outcome
DecreaseTestosterone after treatment cessation
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
TT decreased one month posttreatment to pretreatment values.
1 context sentence(design, population, supporting numbers)
Summary · context
This was a proof-of-principle, randomized, open-label, fixed dose, active-control, two-center phase IIB study in 12 men with secondary hypogonadism treated previously with topical testosterone.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-2353057505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.

Summary

Results from this study8

Studies that did not test the peptide alone2

Version history

Subjects

Publication types

MeSH terms