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Study · Animal study (in vivo) · rat · 2013

5 results

[A comparison of a neuroprotective effects of hypoxic postconditioning and cerebrolysin in the experimental model].

Rybnikova EA, Vorob'ev MG, Pivina SG, Samoĭlov MO

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2013

PMID23528584 (opens in a new tab)PepBankPUB-23528584
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after severe hypoxia, Cerebrolysin protected CA4 neurons, as did hypoxic postconditioning.

    In plain wordsIn rats after severe hypoxia, Cerebrolysin protected CA4 neurons, as did hypoxic postconditioning.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableCA4 neuronal injury and loss
    Study

    ratn: not reported in source

    Posthypoxic pathology after severe hypoxia
    Comparator
    Hypoxic postconditioning
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Postconditioning prevented the injury and loss of hippocampal (fields CA1, CA4) and neocortical neurons whereas cerebrolysin was protective only for CA4 and the neocortex.
    2 context sentences
    Summary · context
    We compared the neuroprotective efficacy of hypoxic postconditioning and cerebrolysin in a model of posthypoxic pathology in rats.
    Summary · context
    Animals that survived the severe hypoxia (180 Torr, 3 h) were exposed to hypoxic postconditioning or received cerebrolysin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after severe hypoxia, Cerebrolysin protected neocortical neurons, as did hypoxic postconditioning.

    In plain wordsIn rats after severe hypoxia, Cerebrolysin protected neocortical neurons, as did hypoxic postconditioning.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableNeocortical neuronal injury and loss
    Study

    ratn: not reported in source

    Posthypoxic pathology after severe hypoxia
    Comparator
    Hypoxic postconditioning
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Postconditioning prevented the injury and loss of hippocampal (fields CA1, CA4) and neocortical neurons whereas cerebrolysin was protective only for CA4 and the neocortex.
    2 context sentences
    Summary · context
    We compared the neuroprotective efficacy of hypoxic postconditioning and cerebrolysin in a model of posthypoxic pathology in rats.
    Summary · context
    Animals that survived the severe hypoxia (180 Torr, 3 h) were exposed to hypoxic postconditioning or received cerebrolysin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after severe hypoxia, Cerebrolysin did not protect CA1 neurons, unlike hypoxic postconditioning.

    In plain wordsIn rats after severe hypoxia, Cerebrolysin did not protect CA1 neurons, unlike hypoxic postconditioning.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableCA1 neuronal injury and loss
    Study

    ratn: not reported in source

    Posthypoxic pathology after severe hypoxia
    Comparator
    Hypoxic postconditioning
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Postconditioning prevented the injury and loss of hippocampal (fields CA1, CA4) and neocortical neurons whereas cerebrolysin was protective only for CA4 and the neocortex.
    2 context sentences
    Summary · context
    We compared the neuroprotective efficacy of hypoxic postconditioning and cerebrolysin in a model of posthypoxic pathology in rats.
    Summary · context
    Animals that survived the severe hypoxia (180 Torr, 3 h) were exposed to hypoxic postconditioning or received cerebrolysin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after severe hypoxia, Cerebrolysin did not normalize anxiety as hypoxic postconditioning did.

    In plain wordsIn rats after severe hypoxia, Cerebrolysin did not normalize anxiety as hypoxic postconditioning did.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableAnxiety normalization
    Study

    ratn: not reported in source

    Posthypoxic pathology after severe hypoxia
    Comparator
    Hypoxic postconditioning
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides that, postconditioning, unlike cerebrolysin, led to the complete functional rehabilitation from the severe hypoxia by normalizing the level of anxiety and the pituitary-adrenal axis activity.
    2 context sentences
    Summary · context
    We compared the neuroprotective efficacy of hypoxic postconditioning and cerebrolysin in a model of posthypoxic pathology in rats.
    Summary · context
    Animals that survived the severe hypoxia (180 Torr, 3 h) were exposed to hypoxic postconditioning or received cerebrolysin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats after severe hypoxia, Cerebrolysin did not normalize pituitary-adrenal axis activity as hypoxic postconditioning did.

    In plain wordsIn rats after severe hypoxia, Cerebrolysin did not normalize pituitary-adrenal hormone system activity as hypoxic postconditioning did.

    Peptide
    Cerebrolysin
    Outcome
    Not applicablePituitary-adrenal axis activity normalization
    Study

    ratn: not reported in source

    Posthypoxic pathology after severe hypoxia
    Comparator
    Hypoxic postconditioning
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides that, postconditioning, unlike cerebrolysin, led to the complete functional rehabilitation from the severe hypoxia by normalizing the level of anxiety and the pituitary-adrenal axis activity.
    2 context sentences
    Summary · context
    We compared the neuroprotective efficacy of hypoxic postconditioning and cerebrolysin in a model of posthypoxic pathology in rats.
    Summary · context
    Animals that survived the severe hypoxia (180 Torr, 3 h) were exposed to hypoxic postconditioning or received cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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