Differential pulsatile secretagogue control of GH secretion in healthy men.

Norman C, Miles J, Bowers CY, Veldhuis JD

American journal of physiology. Regulatory, integrative and comparative physiology13 Mar 2013Cited by 2 (Europe PMC)

PMID23485864PMCIDPMC3652074DOI10.1152/ajpregu.00069.2013PepBankPUB-23485864

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

01HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism
In 26 healthy older men, pulsatile GH secretion correlated positively with testosterone concentrations during combined GHRH pulses and GHRP‑2 infusion.
In plain wordsIn older men, higher testosterone went with more pulsatile growth hormone release when GHRH pulses and GHRP‑2 were given together.
Peptide
GHRP-2
Outcome
IncreasePulsatile GH secretion versus testosterone during GHRH pulses plus GHRP-2
Study
n = 26
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Pulsatile GH secretion correlated positively with T concentrations (270-1,170 ng/dl) in the 26 men
2 context sentences(design, population, supporting numbers)
Summary · context
and combined GHRH pulses/GHRP-2 (P = 0.016, R(2) = 0.25) infusions.
Summary · context
These queries were assessed in a prospectively randomized, placebo-controlled double-blind cohort comprising 26 healthy older men randomized to testosterone (T) vs. placebo supplementation.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2348586401
02HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism
In 26 healthy older men, basal nonpulsatile GH secretion correlated with testosterone during saline pulses with GHRP‑2 drive.
In plain wordsIn older men, testosterone levels were linked to basal growth hormone release while GHRP‑2 was infused.
Peptide
GHRP-2
Outcome
IncreaseBasal nonpulsatile GH secretion versus testosterone during GHRP-2 drive
Study
n = 26
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Basal nonpulsatile GH secretion correlated with T during saline pulses/GHRP-2 drive (P = 0.020, R(2) = 0.16).
1 context sentence(design, population, supporting numbers)
Summary · context
These queries were assessed in a prospectively randomized, placebo-controlled double-blind cohort comprising 26 healthy older men randomized to testosterone (T) vs. placebo supplementation.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2348586402
03HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism
In 26 healthy older men, pulsatile GH secretion varied negatively with body mass index during saline pulses with GHRP‑2 infusion.
In plain wordsIn older men, a higher body mass index was linked to less pulsatile growth hormone release during GHRP‑2 infusion.
Peptide
GHRP-2
Outcome
DecreasePulsatile GH secretion versus BMI during saline pulses plus GHRP-2
Study
n = 26
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
By regression analysis, pulsatile GH secretion varied negatively with body mass index (BMI) during saline/GHRP-2 infusion (P = 0.001, R(2) = 0.36)
1 context sentence(design, population, supporting numbers)
Summary · context
These queries were assessed in a prospectively randomized, placebo-controlled double-blind cohort comprising 26 healthy older men randomized to testosterone (T) vs. placebo supplementation.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2348586403
04HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism
In 26 healthy older men, pulsatile GH secretion varied negatively with body mass index after the triple stimulus preceded by GHRH and GHRP‑2.
In plain wordsIn older men, a higher body mass index was linked to less growth hormone release after a combined GHRH, GHRP‑2 and arginine stimulus.
Peptide
GHRP-2
Outcome
DecreasePulsatile GH secretion versus BMI after triple stimulus preceded by GHRH/GHRP-2
Study
n = 26
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
By regression analysis, pulsatile GH secretion varied negatively with body mass index (BMI) during saline/GHRP-2 infusion (P = 0.001, R(2) = 0.36), as well as after the triple stimulus preceded by GHRH/GHRP-2 (P = 0.013, R(2) = 0.23)
1 context sentence(design, population, supporting numbers)
Summary · context
These queries were assessed in a prospectively randomized, placebo-controlled double-blind cohort comprising 26 healthy older men randomized to testosterone (T) vs. placebo supplementation.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2348586404
05HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism
In 26 healthy older men, mean 10-h GH concentrations under GHRP‑2 were predicted positively by estradiol and negatively by body mass index.
In plain wordsIn older men, GH levels during GHRP‑2 infusion were higher with more estradiol and lower with a higher body mass index.
Peptide
GHRP-2
Outcome
MixedMean 10-h GH concentration under GHRP-2 versus estradiol and BMI
Study
n = 26
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Mean (10-h) GH concentrations under GHRP-2 were predicted jointly by estradiol (positively) and BMI (negatively) (P < 0.001, R(2) = 0.520).
1 context sentence(design, population, supporting numbers)
Summary · context
These queries were assessed in a prospectively randomized, placebo-controlled double-blind cohort comprising 26 healthy older men randomized to testosterone (T) vs. placebo supplementation.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2348586405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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