A molecular model of Lys-Glu and Ala-Glu-Asp-Gly (AEDG) interactions with DNA sites GCAG and ATTTC in gene promoters was built.
In plain wordsA computer model predicted how the peptide AEDG and one other peptide could interact with DNA sites in gene control regions.
- Peptide
- Epitalon
- Outcome
- Not applicableModelled AEDG interaction with promoter DNA sites
- Study
n: not reported in source
molecular mechanics model of peptide-DNA complexes- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.
1 context sentence(design, population, supporting numbers)
Analysis of the main parameters of molecular mechanics (number of hydrogen bonds, hydrophobic and electrostatic interactions, DNA-peptide complex minimization energy) provided the data to validate the previously proposed qualitative models of peptide-DNA interactions and to evaluate their quantitative characteristics.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.