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Study · Ex vivo tissue · 2012

3 results

Role of vasoactive intestinal peptide on the proximal and distal parts from the dentate line in the normal human internal anal sphincter.

Tomita R, Sakurai K, Fujisaki S, Koshinaga T

Hepato-gastroenterology1 Oct 2012Cited by 1 (Europe PMC)

PMID23435134 (opens in a new tab)DOI10.5754/hge10394 (opens in a new tab)PepBankPUB-23435134
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In human internal anal sphincter strips, VIP induced a relaxation response in both proximal and distal parts after adrenergic and cholinergic blockade.

    In plain wordsIn lab tests on human anal sphincter muscle, VIP relaxed both the upper and lower parts.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP-induced relaxation after adrenergic and cholinergic blockade
    Study

    humann = 20

    Human internal anal sphincter muscle strips
    Comparator
    Baseline tone
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    1) Response to VIP after blockade of the adrenergic and cholinergic nerves: VIP showed relaxation reaction in both PIAS and DIAS.
    2 context sentences
    Summary · context
    Normal IAS specimens derived from 20 patients with lower rectal cancer (14 men and 6 women aged from 48 to 77 years, average 66.5 years) were used.
    Summary · context
    A mechanogram was used to evaluate in vitro muscle strip responses to VIP after treatment with various autonomic nerve blockers.
  2. 02LabEx vivo tissueActivity measurement

    In human internal anal sphincter strips, the relaxation response to VIP was significantly greater in the proximal part than in the distal part.

    In plain wordsIn lab tests on human anal sphincter muscle, VIP relaxed the upper part more than the lower part.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP relaxation in proximal versus distal IAS
    Study

    humann = 20

    Human internal anal sphincter muscle strips
    Comparator
    Distal IAS (DIAS)
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The percentage of relaxation responses via VIP nerves in the PIAS was significantly greater than that in the DIAS (p=0.0350).
    2 context sentences
    Summary · context
    Normal IAS specimens derived from 20 patients with lower rectal cancer (14 men and 6 women aged from 48 to 77 years, average 66.5 years) were used.
    Summary · context
    A mechanogram was used to evaluate in vitro muscle strip responses to VIP after treatment with various autonomic nerve blockers.
  3. 03LabEx vivo tissueMechanism

    In human internal anal sphincter strips, VIP responses in both proximal and distal parts were not completely blocked by tetrodotoxin.

    In plain wordsIn lab tests on human anal sphincter muscle, a nerve blocker did not fully stop the VIP response.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Direction not reportedTetrodotoxin blockade of VIP response
    Study

    humann = 20

    Human internal anal sphincter muscle strips
    Comparator
    No tetrodotoxin
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    2) VIP responses in the PIAS and DIAS were not completely blocked by tetrodotoxin.
    2 context sentences
    Summary · context
    Normal IAS specimens derived from 20 patients with lower rectal cancer (14 men and 6 women aged from 48 to 77 years, average 66.5 years) were used.
    Summary · context
    A mechanogram was used to evaluate in vitro muscle strip responses to VIP after treatment with various autonomic nerve blockers.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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