Skip to content

Study · Randomized controlled trial · n = 60 · 2013

2 results

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.

Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J

American journal of clinical dermatology1 Apr 2013Cited by 34 (Europe PMC)

PMID23417317 (opens in a new tab)DOI10.1007/s40257-013-0009-9 (opens in a new tab)PepBankPUB-23417317
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In Chinese subjects, subjective anti-wrinkle efficacy was higher with argireline than placebo.

    In plain wordsIn Chinese subjects, argireline improved wrinkles more than placebo in subjective assessments.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseSubjective anti-wrinkle efficacy
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · 4 weeksAs given in this study (human).

    Measurements

    Anti-wrinkle efficacy
    48.9%
    argireline
    Anti-wrinkle efficacy
    0%
    placebo

    Source sentences

    Summary
    In the subjective evaluation, the total anti-wrinkle efficacy in the argireline group was 48.9 %, compared with 0 % in the placebo group.
    2 context sentences
    Summary · context
    A total of 60 subjects received a randomized treatment of argireline or placebo in a ratio of 3:1.
    Summary · context
    Argireline or placebo was applied to their peri-orbital wrinkles twice daily for 4 weeks, and then evaluations were made for the improvements in wrinkles.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In Chinese subjects, roughness parameters decreased with argireline, while no obvious decrease occurred with placebo.

    In plain wordsIn Chinese subjects, skin roughness decreased with argireline, while placebo showed no obvious decrease.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    DecreaseSkin roughness parameters
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    In the objective evaluation, the parameters of roughness were all decreased in the argireline group (p 0.05).
    2 context sentences
    Summary · context
    A total of 60 subjects received a randomized treatment of argireline or placebo in a ratio of 3:1.
    Summary · context
    Argireline or placebo was applied to their peri-orbital wrinkles twice daily for 4 weeks, and then evaluations were made for the improvements in wrinkles.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.