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Study · Measured the body's own peptide · 2013

2 results

Prolonged treatment with transcutaneous electrical nerve stimulation (TENS) modulates neuro-gastric motility and plasma levels of vasoactive intestinal peptide (VIP), motilin and interleukin-6 (IL-6) in systemic sclerosis.

McNearney TA, Sallam HS, Hunnicutt SE, Doshi D, Chen JD

Clinical and experimental rheumatology7 Feb 2013Cited by 31 (Europe PMC)

PMID23406616 (opens in a new tab)PepBankPUB-23406616
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In patients with systemic sclerosis, the body's own plasma VIP level fell after a single session of transcutaneous electrical nerve stimulation versus baseline.

    In plain wordsIn people with systemic sclerosis, natural VIP levels in blood fell after one session of nerve stimulation compared with baseline.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreasePlasma VIP after acute TENS
    Study

    n = 17

    Comparator
    Baseline
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    Mean plasma VIP and motilin levels were significantly decreased after acute TENS, (vs. baseline), generally maintained in the prolonged TENS intervals.
    1 context sentence
    Summary · context
    Seventeen SSc patients underwent 30 min TENS treatment >10Hz at GI acupuncture points PC6 and ST36, once (acute TENS) and then after two weeks of TENS sessions for 30 min twice daily (prolonged TENS).

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialOther

    In patients with systemic sclerosis, the body's own plasma VIP level stayed generally lower than baseline after two weeks of daily nerve stimulation.

    In plain wordsIn people with systemic sclerosis, natural VIP levels in blood stayed generally lower than baseline after two weeks of nerve stimulation.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreasePlasma VIP after prolonged TENS
    Study

    n = 17

    Comparator
    Baseline
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    Mean plasma VIP and motilin levels were significantly decreased after acute TENS, (vs. baseline), generally maintained in the prolonged TENS intervals.
    2 context sentences
    Summary · context
    lowered plasma VIP, motilin and IL-6 levels
    Summary · context
    Seventeen SSc patients underwent 30 min TENS treatment >10Hz at GI acupuncture points PC6 and ST36, once (acute TENS) and then after two weeks of TENS sessions for 30 min twice daily (prolonged TENS).

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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