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Study · Animal study (in vivo) · mouse · 2013

4 results

Alternative erythropoietin-mediated signaling prevents secondary microvascular thrombosis and inflammation within cutaneous burns.

Bohr S, Patel SJ, Shen K, Vitalo AG, Brines M, Cerami A, Berthiaume F, Yarmush ML

Proceedings of the National Academy of Sciences of the United States of America11 Feb 2013Cited by 48 (Europe PMC)

PMID23401545 (opens in a new tab)PMCIDPMC3587271 (opens in a new tab)DOI10.1073/pnas.1214099110 (opens in a new tab)PepBankPUB-23401545
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with deep partial thickness burns, systemic ARA290 maintained patency of the microvasculature, whereas vehicle-treated wounds showed secondary microvascular thrombosis.

    In plain wordsIn mice with burns, ARA290 kept small blood vessels in the wound open, while vehicle-treated wounds developed clots.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseSecondary microvascular thrombosis (microvascular patency)
    Study

    mousen: not reported in source

    Deep partial thickness cutaneous burn
    Comparator
    Vehicle
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · systemic · At 1, 12 and 24 h postburnAs given in this study (mouse).

    Source sentences

    Summary
    On the other hand, when ARA290 was systemically administered, patency of the microvasculature was maintained.
    2 context sentences
    Summary · context
    With vehicle-only treatment, wounds exhibited secondary microvascular thrombosis within 24 h postburn, and subsequent necrosis of the surrounding tissue, thus converting to a full-thickness injury within 48 h.
    Summary · context
    For this purpose, a deep partial thickness cutaneous burn injury was applied on the back of mice, followed by systemic administration of vehicle or ARA290 at 1, 12, and 24 h postburn.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with deep partial thickness burns, ARA290 mitigated the innate inflammatory response.

    In plain wordsIn mice with burns, ARA290 reduced the early inflammatory response in the wound, compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseInnate inflammatory response in burn wounds
    Study

    mousen: not reported in source

    Deep partial thickness cutaneous burn
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated · systemic · At 1, 12 and 24 h postburnAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, ARA290 mitigated the innate inflammatory response, most notably tumor necrosis factor-alpha-mediated signaling.
    1 context sentence
    Summary · context
    For this purpose, a deep partial thickness cutaneous burn injury was applied on the back of mice, followed by systemic administration of vehicle or ARA290 at 1, 12, and 24 h postburn.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with deep partial thickness burns, ARA290 mitigated tumor necrosis factor-alpha-mediated signaling.

    In plain wordsIn mice with burns, ARA290 reduced signaling from the inflammation messenger TNF-alpha, compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseTNF-α-mediated signaling in burn wounds
    Study

    mousen: not reported in source

    Deep partial thickness cutaneous burn
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated · systemic · At 1, 12 and 24 h postburnAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, ARA290 mitigated the innate inflammatory response, most notably tumor necrosis factor-alpha-mediated signaling.
    1 context sentence
    Summary · context
    For this purpose, a deep partial thickness cutaneous burn injury was applied on the back of mice, followed by systemic administration of vehicle or ARA290 at 1, 12, and 24 h postburn.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with deep partial thickness burns, the effects of ARA290 on thrombosis and inflammation correlated with long-term recovery of initially injured yet viable tissue.

    In plain wordsIn mice with burns, ARA290 effects were linked to long-term recovery of injured but living skin tissue, compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseLong-term recovery of initially injured viable tissue
    Study

    mousen: not reported in source

    Deep partial thickness cutaneous burn
    Comparator
    Vehicle
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · systemic · At 1, 12 and 24 h postburnAs given in this study (mouse).

    Source sentences

    Summary
    These findings correlated with long-term recovery of initially injured yet viable tissue components.
    1 context sentence
    Summary · context
    For this purpose, a deep partial thickness cutaneous burn injury was applied on the back of mice, followed by systemic administration of vehicle or ARA290 at 1, 12, and 24 h postburn.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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