Cost-effectiveness comparison between pituitary down-regulation with a gonadotropin-releasing hormone agonist short regimen on alternate days and an antagonist protocol for assisted fertilization treatments.

Maldonado LG, Franco JG Jr, Setti AS, Iaconelli A Jr, Borges E Jr

Fertility and sterility5 Feb 2013Cited by 17 (Europe PMC)

PMID23394779DOI10.1016/j.fertnstert.2013.01.095PepBankPUB-23394779

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialEfficacy outcome
In assisted fertilization patients, more patients underwent embryo transfer with the cetrorelix protocol than with the triptorelin protocol.
In plain wordsIn assisted fertilization patients, more patients underwent embryo transfer with the cetrorelix protocol than with the triptorelin protocol.
Peptide
Cetrorelix
Outcome
IncreaseEmbryo transfer
Study
n = 96
Comparator
Triptorelin on alternate days with rFSH and rhCG microdose
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
A significantly lower number of patients underwent embryo transfer in the GnRHa group.
4 context sentences(design, population, supporting numbers)
Summary · context
Prospective, randomized.
Summary · context
Patients were randomized into GnRHa (n = 48) and GnRHant (n = 48) groups.
Summary · context
GnRHa stimulation protocol: administration of triptorelin on alternate days starting on the first day of the cycle, recombinant FSH (rFSH), and recombinant hCG (rhCG) microdose.
Summary · context
GnRHant protocol: administration of a daily dose of rFSH, cetrorelix, and rhCG microdose.
Report a problemFND-2339477901
02HumanRandomized controlled trialEfficacy outcome
In assisted fertilization patients, clinical pregnancy rates were significantly higher with the cetrorelix protocol than with the triptorelin protocol.
In plain wordsIn assisted fertilization patients, pregnancy rates were higher with the cetrorelix protocol than with the triptorelin protocol.
Peptide
Cetrorelix
Outcome
IncreaseClinical pregnancy rate
Study
n = 96
Comparator
Triptorelin on alternate days with rFSH and rhCG microdose
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Clinical pregnancy rate was significantly lower and miscarriage rate was significantly higher in the GnRHa group.
4 context sentences(design, population, supporting numbers)
Summary · context
Prospective, randomized.
Summary · context
Patients were randomized into GnRHa (n = 48) and GnRHant (n = 48) groups.
Summary · context
GnRHa stimulation protocol: administration of triptorelin on alternate days starting on the first day of the cycle, recombinant FSH (rFSH), and recombinant hCG (rhCG) microdose.
Summary · context
GnRHant protocol: administration of a daily dose of rFSH, cetrorelix, and rhCG microdose.
Report a problemFND-2339477902
03HumanRandomized controlled trialSafety outcome
In assisted fertilization patients, miscarriage rates were significantly lower with the cetrorelix protocol than with the triptorelin protocol.
In plain wordsIn assisted fertilization patients, miscarriage rates were lower with the cetrorelix protocol than with the triptorelin protocol.
Peptide
Cetrorelix
Outcome
DecreaseMiscarriage rate
Study
n = 96
Comparator
Triptorelin on alternate days with rFSH and rhCG microdose
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Clinical pregnancy rate was significantly lower and miscarriage rate was significantly higher in the GnRHa group.
4 context sentences(design, population, supporting numbers)
Summary · context
Prospective, randomized.
Summary · context
Patients were randomized into GnRHa (n = 48) and GnRHant (n = 48) groups.
Summary · context
GnRHa stimulation protocol: administration of triptorelin on alternate days starting on the first day of the cycle, recombinant FSH (rFSH), and recombinant hCG (rhCG) microdose.
Summary · context
GnRHant protocol: administration of a daily dose of rFSH, cetrorelix, and rhCG microdose.
Report a problemFND-2339477903
04HumanRandomized controlled trialEfficacy outcome
In assisted fertilization patients, cetrorelix protocol cycle costs exceeded triptorelin protocol costs ($5,900.40 ± 472.50 versus $5,327.80 ± 387.30).
In plain wordsIn assisted fertilization patients, cycle costs were higher with the cetrorelix protocol than with the triptorelin protocol.
Peptide
Cetrorelix
Outcome
IncreaseCost per cycle
Study
n = 96
Comparator
Triptorelin on alternate days with rFSH and rhCG microdose
Outcome group
Treatment Costs · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Cost per cycle
5900.4 dollars
cetrorelix protocol
Cost per cycle
5327.8 dollars
triptorelin protocol
Source sentences
Summary
It was observed a significant lower cost per cycle in the GnRHa group compared with the GnRHant group ($5,327.80 ± 387.30 vs. $5,900.40 ± 472.50).
4 context sentences(design, population, supporting numbers)
Summary · context
Prospective, randomized.
Summary · context
Patients were randomized into GnRHa (n = 48) and GnRHant (n = 48) groups.
Summary · context
GnRHa stimulation protocol: administration of triptorelin on alternate days starting on the first day of the cycle, recombinant FSH (rFSH), and recombinant hCG (rhCG) microdose.
Summary · context
GnRHant protocol: administration of a daily dose of rFSH, cetrorelix, and rhCG microdose.
Report a problemFND-2339477904
05HumanRandomized controlled trialEfficacy outcome
In assisted fertilization patients, cetrorelix protocol pregnancy costs were lower than triptorelin protocol costs ($11,328.70 ± 907.20 versus $19,671.80 ± 1,430.00).
In plain wordsIn assisted fertilization patients, pregnancy costs were lower with the cetrorelix protocol than with the triptorelin protocol.
Peptide
Cetrorelix
Outcome
DecreaseCost per pregnancy
Study
n = 96
Comparator
Triptorelin on alternate days with rFSH and rhCG microdose
Outcome group
Treatment Costs · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Cost per pregnancy
11328.7 dollars
cetrorelix protocol
Cost per pregnancy
19671.8 dollars
triptorelin protocol
Source sentences
Summary
However, mean cost per pregnancy in the GnRHa was higher than in the GnRHant group ($19,671.80 ± 1,430.00 vs. $11,328.70 ± 907.20).
4 context sentences(design, population, supporting numbers)
Summary · context
Prospective, randomized.
Summary · context
Patients were randomized into GnRHa (n = 48) and GnRHant (n = 48) groups.
Summary · context
GnRHa stimulation protocol: administration of triptorelin on alternate days starting on the first day of the cycle, recombinant FSH (rFSH), and recombinant hCG (rhCG) microdose.
Summary · context
GnRHant protocol: administration of a daily dose of rFSH, cetrorelix, and rhCG microdose.
Report a problemFND-2339477905

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT01468441

Ovarian Stimulation Using Recombinant Follicle-stimulating Hormone (FSH) and Gonadotrophin Releasing Hormone (GnRH) Agonist in Alternate Days

Fertility - Assisted Fertilization Centern = 96Sept 2011 to Mar 2012

Infertility

Trial page ClinicalTrials.govUpdated 13 Jul 2012

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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