Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo.

Orth P, Cucchiarini M, Zurakowski D, Menger MD, Kohn DM, Madry H

Osteoarthritis and cartilage24 Jan 2013Cited by 60 (Europe PMC)

PMID23353669DOI10.1016/j.joca.2013.01.008PepBankPUB-23353669

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rabbits with osteochondral defects, PTH increased PTH1R expression in repair-tissue chondrocytes.
In plain wordsIn rabbits, PTH increased receptor expression in cartilage repair cells compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePTH1R expression in chondrocytes
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
Systemic PTH [1-34] increased PTH1R expression on both, chondrocytes and osteocytes within the repair tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366901
02AnimalAnimal study (in vivo)Mechanism
In rabbits with osteochondral defects, PTH increased PTH1R expression in repair-tissue osteocytes.
In plain wordsIn rabbits, PTH increased receptor expression in bone repair cells compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePTH1R expression in osteocytes
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
Systemic PTH [1-34] increased PTH1R expression on both, chondrocytes and osteocytes within the repair tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366902
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH improved macroscopic and microscopic appearance of cartilaginous repair tissue compared with saline.
In plain wordsIn rabbits, PTH improved cartilage repair tissue appearance compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCartilaginous repair tissue appearance
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
PTH [1-34] ameliorated the macro- and microscopic aspect of the cartilaginous repair tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366903
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH increased subchondral bone plate thickness within defects compared with saline.
In plain wordsIn rabbits, PTH increased bone plate thickness under cartilage defects compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSubchondral bone plate thickness
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
It also enhanced the thickness of the subchondral bone plate and the microarchitecture of the subarticular spongiosa within the defects.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366904
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH improved subarticular spongiosa microarchitecture within defects compared with saline.
In plain wordsIn rabbits, PTH improved the structure of bone under cartilage defects compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSubarticular spongiosa microarchitecture
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
It also enhanced the thickness of the subchondral bone plate and the microarchitecture of the subarticular spongiosa within the defects.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366905
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH did not significantly affect apoptosis compared with saline.
In plain wordsIn rabbits, PTH did not significantly change cell death compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeApoptosis
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
Apoptotic levels, synovial membrane, biochemical composition of the repair tissue, and type-I/II collagen immunoreactivity remained unaffected.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366906
07AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH did not significantly affect the synovial membrane compared with saline.
In plain wordsIn rabbits, PTH did not significantly change the joint lining compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeSynovial membrane
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
Apoptotic levels, synovial membrane, biochemical composition of the repair tissue, and type-I/II collagen immunoreactivity remained unaffected.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366907
08AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH did not significantly affect repair tissue biochemical composition compared with saline.
In plain wordsIn rabbits, PTH did not significantly change repair tissue composition compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeRepair tissue biochemical composition
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
Apoptotic levels, synovial membrane, biochemical composition of the repair tissue, and type-I/II collagen immunoreactivity remained unaffected.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366908
09AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH did not affect type-I collagen immunoreactivity compared with saline.
In plain wordsIn rabbits, PTH did not change type-I collagen staining compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeType-I collagen immunoreactivity
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
Apoptotic levels, synovial membrane, biochemical composition of the repair tissue, and type-I/II collagen immunoreactivity remained unaffected.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366909
10AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH did not affect type-II collagen immunoreactivity compared with saline.
In plain wordsIn rabbits, PTH did not change type-II collagen staining compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeType-II collagen immunoreactivity
Study
rabbitn = 8
femoral trochlear osteochondral defects
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).
Source sentences
Summary
Apoptotic levels, synovial membrane, biochemical composition of the repair tissue, and type-I/II collagen immunoreactivity remained unaffected.
2 context sentences(design, population, supporting numbers)
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8).
Summary · context
Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
Report a problemFND-2335366910

Studies that did not test the peptide alone1

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

11AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In rabbits with osteochondral defects, cartilage and subchondral bone repair processes did not correlate significantly.
In plain wordsIn rabbits, cartilage repair and underlying bone repair did not have a significant association.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeCartilage and subchondral bone repair correlation
Study
rabbitn: not reported in source
femoral trochlear osteochondral defects
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
No significant correlations were established between these coexistent processes.
2 context sentences(design, population, supporting numbers)
Summary · context
PTH [1-34] ameliorated the macro- and microscopic aspect of the cartilaginous repair tissue. It also enhanced the thickness of the subchondral bone plate and the microarchitecture of the subarticular spongiosa within the defects.
Summary · context
Standardized cylindrical osteochondral defects were bilaterally created in the femoral trochlea of rabbits (n = 8). Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to the treatment group (n = 4) for 6 weeks, controls (n = 4) received saline.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2335366911

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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