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Study · Animal study (in vivo) · mouse · 2013

8 results

Thymosin alpha-1-transformed Bifidobacterium promotes T cell proliferation and maturation in mice by oral administration.

Shao C, Tian G, Huang Y, Liang W, Zheng H, Wei J, Wei C, Yang C, Wang H, Zeng W

International immunopharmacology24 Jan 2013Cited by 15 (Europe PMC)

PMID23352493 (opens in a new tab)DOI10.1016/j.intimp.2012.12.031 (opens in a new tab)PepBankPUB-23352493
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Balb/c mice, orally given thymosin α1-transformed B. longum increased CD3+CD4+ T cells in blood, spleen and thymus versus the empty-vector strain.

    In plain wordsIn mice, oral thymosin α1-producing bacteria raised CD3+CD4+ T cell numbers more than bacteria without the gene.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD3+CD4+ T cells in blood, spleen and thymus
    Study

    mousen: not reported in source

    Balb/c mice
    Comparator
    Empty-vector B. longum (BL-0)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results shown that (1) the CD3(+)CD4(+) and CD3(+)CD8(+) T-cells in blood, spleen and thymus, and the CD4(+)CD8(+) cells in thymus and spleen of BL-Tα1 group were all significantly increased than that of negative control BL-0 group respectively; (2) the interferon-γ (IFN-γ) and interleukin-12 (I…
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Balb/c mice, orally given thymosin α1-transformed B. longum increased CD3+CD8+ T cells in blood, spleen and thymus versus the empty-vector strain.

    In plain wordsIn mice, oral thymosin α1-producing bacteria raised CD3+CD8+ T cell numbers more than bacteria without the gene.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD3+CD8+ T cells in blood, spleen and thymus
    Study

    mousen: not reported in source

    Balb/c mice
    Comparator
    Empty-vector B. longum (BL-0)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results shown that (1) the CD3(+)CD4(+) and CD3(+)CD8(+) T-cells in blood, spleen and thymus, and the CD4(+)CD8(+) cells in thymus and spleen of BL-Tα1 group were all significantly increased than that of negative control BL-0 group respectively; (2) the interferon-γ (IFN-γ) and interleukin-12 (I…
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Balb/c mice, orally given thymosin α1-transformed B. longum increased CD4+CD8+ cells in thymus and spleen versus the empty-vector strain.

    In plain wordsIn mice, oral thymosin α1-producing bacteria raised CD4+CD8+ cell numbers more than bacteria without the gene.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD4+CD8+ cells in thymus and spleen
    Study

    mousen: not reported in source

    Balb/c mice
    Comparator
    Empty-vector B. longum (BL-0)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results shown that (1) the CD3(+)CD4(+) and CD3(+)CD8(+) T-cells in blood, spleen and thymus, and the CD4(+)CD8(+) cells in thymus and spleen of BL-Tα1 group were all significantly increased than that of negative control BL-0 group respectively; (2) the interferon-γ (IFN-γ) and interleukin-12 (I…
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Balb/c mice, orally given thymosin α1-transformed B. longum increased serum IFN-γ versus the empty-vector strain.

    In plain wordsIn mice, oral thymosin α1-producing bacteria raised blood IFN-γ more than bacteria without the gene.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSerum interferon-γ
    Study

    mousen: not reported in source

    Balb/c mice
    Comparator
    Empty-vector B. longum (BL-0)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results shown that (1) the CD3(+)CD4(+) and CD3(+)CD8(+) T-cells in blood, spleen and thymus, and the CD4(+)CD8(+) cells in thymus and spleen of BL-Tα1 group were all significantly increased than that of negative control BL-0 group respectively; (2) the interferon-γ (IFN-γ) and interleukin-12 (I…
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In Balb/c mice, orally given thymosin α1-transformed B. longum increased serum IL-12 versus the empty-vector strain.

    In plain wordsIn mice, oral thymosin α1-producing bacteria raised blood IL-12 more than bacteria without the gene.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSerum interleukin-12
    Study

    mousen: not reported in source

    Balb/c mice
    Comparator
    Empty-vector B. longum (BL-0)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results shown that (1) the CD3(+)CD4(+) and CD3(+)CD8(+) T-cells in blood, spleen and thymus, and the CD4(+)CD8(+) cells in thymus and spleen of BL-Tα1 group were all significantly increased than that of negative control BL-0 group respectively; (2) the interferon-γ (IFN-γ) and interleukin-12 (I…
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In Balb/c mice, orally given thymosin α1-transformed B. longum did not significantly change TNF-α versus the empty-vector strain.

    In plain wordsIn mice, oral thymosin α1-producing bacteria did not change TNF-α compared with bacteria without the gene.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSerum TNF-α
    Study

    mousen: not reported in source

    Balb/c mice
    Comparator
    Empty-vector B. longum (BL-0)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    No significant differences were found in the levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) between BL-Tα1 group and BL-0 group
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In Balb/c mice, orally given thymosin α1-transformed B. longum did not significantly change IL-4 versus the empty-vector strain.

    In plain wordsIn mice, oral thymosin α1-producing bacteria did not change IL-4 compared with bacteria without the gene.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSerum interleukin-4
    Study

    mousen: not reported in source

    Balb/c mice
    Comparator
    Empty-vector B. longum (BL-0)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    No significant differences were found in the levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) between BL-Tα1 group and BL-0 group
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.
  8. 08AnimalAnimal study (in vivo)Safety outcome

    In Balb/c mice, three months of orally given thymosin α1-transformed B. longum was followed by thymic hyperplasia and lymphadenectasis.

    In plain wordsIn mice, three months of oral thymosin α1-producing bacteria was followed by enlarged thymus and lymph nodes.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseThymic hyperplasia and lymphadenectasis
    Study

    mousen: not reported in source

    Balb/c mice
    Outcome group
    Adverse events · Immune and inflammation
    Studied dose
    Dose not stated · oral · 3 monthsAs given in this study (mouse).

    Source sentences

    Summary
    thymic hyperplasia and lymphadenectasis were observed in BL-Tα1 group after three-month treatment.
    2 context sentences
    Summary · context
    The Balb/c mice were treated with BL-Tα1, which was pre-induced with 0.2% l-arabinose, every other day for 2 weeks.
    Summary · context
    The B. longum transformed with empty vector (BL-0) was used as the negative control, and normal saline (NS, 0.9% saline) was used as the blank control.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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