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Study · Randomized controlled trial · n = 80 · 2013

2 results

Effects of intranasal oxytocin prior to encoding and retrieval on recognition memory.

Weigand A, Feeser M, Gärtner M, Brandt E, Fan Y, Fuge P, Böker H, Bajbouj M, Grimm S

Psychopharmacology19 Jan 2013Cited by 20 (Europe PMC)

PMID23334103 (opens in a new tab)DOI10.1007/s00213-012-2962-z (opens in a new tab)PepBankPUB-23334103
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy young men, the memory-improving effect of oxytocin was more pronounced when participants had been told to increase their negative emotions during encoding.

    In plain wordsIn healthy young men, oxytocin helped memory more when they had been told to increase their negative emotions while viewing the pictures.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin memory effect by emotion regulation instruction
    Study

    n = 80

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Regarding the influence of emotion regulation, the promnestic effect of OXT was more pronounced when participants had been instructed to increase their negative emotions during encoding.
    1 context sentence
    Summary · context
    In a double-blind, placebo-controlled design, 80 healthy young males performed an emotion regulation task followed by a surprising recognition memory task after 60 min.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy young men, repeated intranasal oxytocin improved memory certainty for negative social stimuli compared with placebo.

    In plain wordsIn healthy young men, repeated oxytocin through the nose made them more certain of their memory for negative social pictures than placebo did.

    Peptide
    Oxytocin
    Outcome
    IncreaseMemory certainty for negative social stimuli
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · repeated administration before encoding and retrievalAs given in this study (human).

    Source sentences

    Summary
    Results show that repeated OXT administration significantly improved memory certainty for negative social stimuli.
    2 context sentences
    Summary · context
    We investigated the influence of a single (prior to encoding) and a repeated (prior to encoding and retrieval) intranasal administration of OXT on recognition memory for stimuli taken from the International Affective Picture System.
    Summary · context
    In a double-blind, placebo-controlled design, 80 healthy young males performed an emotion regulation task followed by a surprising recognition memory task after 60 min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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