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Study · Animal study (in vivo) · minipigs · 2013

10 results

Effects of a TREM-like transcript 1-derived peptide during hypodynamic septic shock in pigs.

Derive M, Boufenzer A, Bouazza Y, Groubatch F, Alauzet C, Barraud D, Lozniewski A, Leroy P, Tran N, Gibot S

Shock (Augusta, Ga.)1 Feb 2013Cited by 49 (Europe PMC)

PMID23324887 (opens in a new tab)DOI10.1097/shk.0b013e31827bcdfb (opens in a new tab)PepBankPUB-23324887
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 attenuated hypotension versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 reduced low blood pressure versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseHypotension
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These disorders were largely attenuated by LR12.
    2 context sentences
    Summary · context
    Peritonitis induced profound hypotension, myocardial dysfunction, lactic acidosis, coagulation abnormalities, and multiple organ failure.
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 attenuated myocardial dysfunction versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 reduced heart dysfunction versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseMyocardial dysfunction
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These disorders were largely attenuated by LR12.
    2 context sentences
    Summary · context
    Peritonitis induced profound hypotension, myocardial dysfunction, lactic acidosis, coagulation abnormalities, and multiple organ failure.
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 attenuated lactic acidosis versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 reduced lactic acidosis versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseLactic acidosis
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These disorders were largely attenuated by LR12.
    2 context sentences
    Summary · context
    Peritonitis induced profound hypotension, myocardial dysfunction, lactic acidosis, coagulation abnormalities, and multiple organ failure.
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 attenuated coagulation abnormalities versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 reduced clotting abnormalities versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseCoagulation abnormalities
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These disorders were largely attenuated by LR12.
    2 context sentences
    Summary · context
    Peritonitis induced profound hypotension, myocardial dysfunction, lactic acidosis, coagulation abnormalities, and multiple organ failure.
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 attenuated multiple organ failure versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 reduced multiple organ failure versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseMultiple organ failure
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Intensive care and hospital outcomes · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These disorders were largely attenuated by LR12.
    2 context sentences
    Summary · context
    Peritonitis induced profound hypotension, myocardial dysfunction, lactic acidosis, coagulation abnormalities, and multiple organ failure.
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 improved mean arterial pressure versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 improved mean arterial pressure versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseMean arterial pressure
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In particular, cardiovascular failure was dampened as attested by a better mean arterial pressure, cardiac index, cardiac power index, and S(v)O(2), despite lower norepinephrine requirements.
    1 context sentence
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 improved cardiac index versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 improved cardiac index versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseCardiac index
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In particular, cardiovascular failure was dampened as attested by a better mean arterial pressure, cardiac index, cardiac power index, and S(v)O(2), despite lower norepinephrine requirements.
    1 context sentence
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 improved cardiac power index versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 improved cardiac power index versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseCardiac power index
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In particular, cardiovascular failure was dampened as attested by a better mean arterial pressure, cardiac index, cardiac power index, and S(v)O(2), despite lower norepinephrine requirements.
    1 context sentence
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 improved S(v)O(2) versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 improved venous oxygen saturation versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseMixed venous oxygen saturation
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In particular, cardiovascular failure was dampened as attested by a better mean arterial pressure, cardiac index, cardiac power index, and S(v)O(2), despite lower norepinephrine requirements.
    1 context sentence
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with septic shock, LR12 lowered norepinephrine requirements versus vehicle.

    In plain wordsIn minipigs with septic shock, LR12 lowered norepinephrine requirements versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseNorepinephrine requirements
    Study

    minipigsn = 11

    fecal peritonitis septic shock
    Comparator
    Normal saline vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In particular, cardiovascular failure was dampened as attested by a better mean arterial pressure, cardiac index, cardiac power index, and S(v)O(2), despite lower norepinephrine requirements.
    1 context sentence
    Summary · context
    Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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