Epidermal growth factor and growth hormone-releasing peptide-6: combined therapeutic approach in experimental stroke.

García Del Barco-Herrera D, Martínez NS, Coro-Antich RM, Machado JM, Alba JS, Salgueiro SR, Acosta JB

Restorative neurology and neuroscience1 Jan 2013Cited by 8 (Europe PMC)

PMID23314006DOI10.3233/rnn-120262PepBankPUB-23314006

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In gerbils with global brain ischemia, EGF plus GHRP6 reduced clinical manifestations.
In plain wordsIn gerbils with brain ischemia, EGF plus GHRP6 reduced clinical signs.
Peptide
GHRP-6
Outcome
DecreaseClinical manifestations
Study
Mongolian gerbiln: not reported in source
Global brain ischemia after carotid occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
EGF+GHRP6 co-administration reduced clinical manifestations and infarct volume and preserved neuronal density.
2 context sentences(design, population, supporting numbers)
Summary · context
Brain global ischemia was generated in Mongolian gerbils by 15 minutes of carotid occlusion.
Summary · context
After reperfusion, EGF, GHRP6 or EGF+GHRP6 were intraperitoneally administered.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2331400601
02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In gerbils with global brain ischemia, EGF plus GHRP6 reduced infarct volume.
In plain wordsIn gerbils with brain ischemia, EGF plus GHRP6 reduced the volume of damaged brain tissue.
Peptide
GHRP-6
Outcome
DecreaseInfarct volume
Study
Mongolian gerbiln: not reported in source
Global brain ischemia after carotid occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
EGF+GHRP6 co-administration reduced clinical manifestations and infarct volume and preserved neuronal density.
2 context sentences(design, population, supporting numbers)
Summary · context
Brain global ischemia was generated in Mongolian gerbils by 15 minutes of carotid occlusion.
Summary · context
After reperfusion, EGF, GHRP6 or EGF+GHRP6 were intraperitoneally administered.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2331400602
03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In gerbils with global brain ischemia, EGF plus GHRP6 preserved neuronal density.
In plain wordsIn gerbils with brain ischemia, EGF plus GHRP6 preserved brain cell density.
Peptide
GHRP-6
Outcome
Not applicableNeuronal density
Study
Mongolian gerbiln: not reported in source
Global brain ischemia after carotid occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
EGF+GHRP6 co-administration reduced clinical manifestations and infarct volume and preserved neuronal density.
2 context sentences(design, population, supporting numbers)
Summary · context
Brain global ischemia was generated in Mongolian gerbils by 15 minutes of carotid occlusion.
Summary · context
After reperfusion, EGF, GHRP6 or EGF+GHRP6 were intraperitoneally administered.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2331400603
04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In gerbils receiving EGF plus GHRP6, Circle of Willis anastomosis grade did not correlate with clinical manifestations, unlike vehicle-treated animals.
In plain wordsIn gerbils receiving EGF plus GHRP6, arterial connection grade did not correlate with clinical signs, unlike vehicle-treated animals.
Peptide
GHRP-6
Outcome
No significant changeAnastomosis grade and clinical manifestations
Study
Mongolian gerbiln: not reported in source
Global brain ischemia after carotid occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
No correlation was observed between the grade of anastomosis of the Circle of Willis and clinical manifestations in the animals receiving EGF+GHRP6, as opposed to the vehicle-treated gerbils.
2 context sentences(design, population, supporting numbers)
Summary · context
Brain global ischemia was generated in Mongolian gerbils by 15 minutes of carotid occlusion.
Summary · context
After reperfusion, EGF, GHRP6 or EGF+GHRP6 were intraperitoneally administered.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2331400604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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