In rats with cecal ligation and puncture sepsis, oxytocin abolished the EMG changes (reduced compound muscle action potential amplitude, prolonged distal latency) seen in untreated septic rats.
In plain wordsIn septic rats, oxytocin prevented the nerve and muscle signal changes seen in untreated septic rats.
- Peptide
- Oxytocin
- Outcome
- MixedEMG alterations (compound muscle action potential amplitude and distal latency)
- Study
ratn: not reported in source
cecal ligation and puncture sepsis model- Comparator
- CLP group
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 0.4, 0.8 and 1.6 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
The administration of MEL and OT to rats significantly abolished the EMG alterations and suppressed oxidative stress and TNF-α release in CLP-induced rats.
4 context sentences(design, population, supporting numbers)
EMG findings revealed that compound muscle action potential amplitude was significantly decreased and distal latency was prolonged in the CLP group compared with the sham group (P < 0.05 and P < 0.0005).
One hundred adult male Sprague-Dawley rats were included in the study.
The cecal ligation and puncture (CLP) procedure was performed to induce the sepsis model.
MEL (10, 20, and 40 mg/kg), OT (0.4, 0.8, and 1.6 mg/kg), and a combination of MEL (20 mg/kg) and OT (0.8 mg/kg) were administered intraperitoneally in the first hour of surgery.