In protease digestion assays, synthetic macrocyclic mimics of oxytocin and vasopressin degraded less and/or more slowly than the parent hormones, oxytocin included, and a linear control peptide.
In plain wordsIn lab tests, synthetic copies of oxytocin and vasopressin broke down less or more slowly than the natural hormones.
- Peptide
- Oxytocin
- Outcome
- Not applicableProtease stability of macrocyclic oxytocin mimic versus parent hormone
- Study
n: not reported in source
pepsin, alpha-chymotrypsin and pronase digestion assay with glutathione- Comparator
- Parent hormones and a linear control peptide
- Outcome group
- Formulation, delivery and stability · Pharmacology
Source sentences
Subsequently, we discovered each of our mimics withstood protease treatment with less degradation and/or a slower rate of degradation as compared to both parent hormones and a linear control peptide.
1 context sentence(design, population, supporting numbers)
Making notable changes to the overall structure and composition of the parent hormones, we synthesized the mimics and tested their durability against treatment with three proteases chosen for their specificity: pepsin, alpha-chymotrypsin, and pronase.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.