Skip to content

Study · Animal study (in vivo) · pig · 2013

4 results

ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury.

van Rijt WG, Nieuwenhuijs-Moeke GJ, van Goor H, Jespersen B, Ottens PJ, Ploeg RJ, Leuvenink HG

Journal of translational medicine9 Jan 2013Cited by 32 (Europe PMC)

PMID23302512 (opens in a new tab)PMCIDPMC3567997 (opens in a new tab)DOI10.1186/1479-5876-11-9 (opens in a new tab)PepBankPUB-23302512
Download PDFPubMedAsk about this study
Jump to 4 results

Summary

BackgroundIn contrast with various pre-clinical studies, recent clinical trials suggest that high dose erythropoietin (EPO) treatment following kidney transplantation does not improve short-term outcome and that it even increases the risk of thrombotic events. ARA290 is a non-erythropoietic EPO derivative and does not increase the risk of cardiovascular events, but potentially has cytoprotective capacities in prevention of renal ischemia/reperfusion injury.MethodsEight female Dutch Landrace pigs were exposed to unilateral renal ischemia for 45 minutes with simultaneous cannulation of the ureter of the ischemic kidney. ARA290 or saline was administered by an intravenous injection at 0, 2, 4 and 6 hours post-reperfusion. The animals were sacrificed seven days post-reperfusion.ResultsARA290 increased glomerular filtration rate during the observation period of seven days. Furthermore, ARA290 tended to reduce MCP-1 and IL-6 expression 15 minutes post-reperfusion. Seven days post-reperfusion ARA290 reduced interstitial fibrosis.ConclusionsThe improvement in renal function following renal ischemia/reperfusion and reduced structural damage observed in this study by ARA290 warrants further investigation towards clinical application.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with renal ischemia/reperfusion, ARA290 increased glomerular filtration rate over the seven-day observation period.

    In plain wordsIn pigs with kidney injury, ARA290 raised kidney filtering rate over seven days, compared with saline.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseGlomerular filtration rate
    Study

    pign = 8

    Renal ischemia/reperfusion injury
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · Doses at 0, 2, 4 and 6 hours post-reperfusionAs given in this study (pig).

    Source sentences

    Summary
    ARA290 increased glomerular filtration rate during the observation period of seven days.
    1 context sentence
    Summary · context
    Eight female Dutch Landrace pigs were exposed to unilateral renal ischemia for 45 minutes with simultaneous cannulation of the ureter of the ischemic kidney. ARA290 or saline was administered by an intravenous injection at 0, 2, 4 and 6 hours post-reperfusion.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In pigs with renal ischemia/reperfusion, ARA290 tended to reduce MCP-1 expression 15 minutes post-reperfusion (a trend).

    In plain wordsIn pigs with kidney injury, ARA290 showed a trend toward lower MCP-1, an inflammation signal, compared with saline.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeMCP-1 expression 15 minutes post-reperfusion
    Study

    pign = 8

    Renal ischemia/reperfusion injury
    Comparator
    Saline
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · Doses at 0, 2, 4 and 6 hours post-reperfusionAs given in this study (pig).

    Source sentences

    Summary
    Furthermore, ARA290 tended to reduce MCP-1 and IL-6 expression 15 minutes post-reperfusion.
    1 context sentence
    Summary · context
    Eight female Dutch Landrace pigs were exposed to unilateral renal ischemia for 45 minutes with simultaneous cannulation of the ureter of the ischemic kidney. ARA290 or saline was administered by an intravenous injection at 0, 2, 4 and 6 hours post-reperfusion.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In pigs with renal ischemia/reperfusion, ARA290 tended to reduce IL-6 expression 15 minutes post-reperfusion (a trend).

    In plain wordsIn pigs with kidney injury, ARA290 showed a trend toward lower IL-6, an inflammation signal, compared with saline.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeIL-6 expression 15 minutes post-reperfusion
    Study

    pign = 8

    Renal ischemia/reperfusion injury
    Comparator
    Saline
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · Doses at 0, 2, 4 and 6 hours post-reperfusionAs given in this study (pig).

    Source sentences

    Summary
    Furthermore, ARA290 tended to reduce MCP-1 and IL-6 expression 15 minutes post-reperfusion.
    1 context sentence
    Summary · context
    Eight female Dutch Landrace pigs were exposed to unilateral renal ischemia for 45 minutes with simultaneous cannulation of the ureter of the ischemic kidney. ARA290 or saline was administered by an intravenous injection at 0, 2, 4 and 6 hours post-reperfusion.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with renal ischemia/reperfusion, ARA290 reduced interstitial fibrosis seven days post-reperfusion.

    In plain wordsIn pigs with kidney injury, ARA290 reduced scarring in kidney tissue at seven days, compared with saline.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseInterstitial fibrosis at day 7
    Study

    pign = 8

    Renal ischemia/reperfusion injury
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · Doses at 0, 2, 4 and 6 hours post-reperfusionAs given in this study (pig).

    Source sentences

    Summary
    Seven days post-reperfusion ARA290 reduced interstitial fibrosis.
    1 context sentence
    Summary · context
    Eight female Dutch Landrace pigs were exposed to unilateral renal ischemia for 45 minutes with simultaneous cannulation of the ureter of the ischemic kidney. ARA290 or saline was administered by an intravenous injection at 0, 2, 4 and 6 hours post-reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.