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Study · Animal study (in vivo) · rat · 2013

4 results

Promotion of peri-implant bone healing by systemically administered parathyroid hormone (1-34) and zoledronic acid adsorbed onto the implant surface.

Li YF, Li XD, Bao CY, Chen QM, Zhang H, Hu J

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA8 Jan 2013Cited by 49 (Europe PMC)

PMID23296744 (opens in a new tab)DOI10.1007/s00198-012-2258-5 (opens in a new tab)PepBankPUB-23296744
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH improved peri-implant bone healing compared with control.

    In plain wordsIn rats, PTH improved bone healing around implants compared with control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeri-implant bone healing
    Study

    ratn: not reported in source

    ovariectomized rats with tibial implants
    Comparator
    Control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg three times a week · subcutaneous · 12 weeksAs given in this study (rat).

    Source sentences

    Summary
    All treatments promoted bone healing around implant compared to control, but PTH+ZA treatment showed significantly stronger effects than PTH or ZA alone in histological, micro-CT, and biomechanical tests.
    2 context sentences
    Summary · context
    The effect of human parathyroid hormone 1-34 (PTH) and zoledronic acid (ZA) alone or in combination on bone healing in osteoporotic settings was tested using implants inserted in tibiae of ovariectomized (OVX) rats.
    Summary · context
    Subsequently, half of the animals from each group also received subcutaneous injections of PTH (60 μg/kg, three times a week) for 12 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH plus ZA improved peri-implant bone healing more than ZA alone.

    In plain wordsIn rats, PTH plus ZA improved bone healing around implants more than ZA alone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeri-implant bone healing with ZA
    Study

    ratn: not reported in source

    ovariectomized rats with tibial implants
    Comparator
    ZA alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg three times a week · subcutaneous · 12 weeksAs given in this study (rat).

    Source sentences

    Summary
    All treatments promoted bone healing around implant compared to control, but PTH+ZA treatment showed significantly stronger effects than PTH or ZA alone in histological, micro-CT, and biomechanical tests.
    2 context sentences
    Summary · context
    The effect of human parathyroid hormone 1-34 (PTH) and zoledronic acid (ZA) alone or in combination on bone healing in osteoporotic settings was tested using implants inserted in tibiae of ovariectomized (OVX) rats.
    Summary · context
    Subsequently, half of the animals from each group also received subcutaneous injections of PTH (60 μg/kg, three times a week) for 12 weeks.

Studies that did not test the peptide alone2

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

  1. 03AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH plus ZA improved peri-implant bone healing more than PTH alone.

    In plain wordsIn rats, PTH plus ZA improved bone healing around implants more than PTH alone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeri-implant bone healing with ZA
    Study

    ratn: not reported in source

    ovariectomized rats with tibial implants
    Comparator
    PTH alone
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    All treatments promoted bone healing around implant compared to control, but PTH+ZA treatment showed significantly stronger effects than PTH or ZA alone in histological, micro-CT, and biomechanical tests.
    2 context sentences
    Summary · context
    The effect of human parathyroid hormone 1-34 (PTH) and zoledronic acid (ZA) alone or in combination on bone healing in osteoporotic settings was tested using implants inserted in tibiae of ovariectomized (OVX) rats.
    Summary · context
    Subsequently, half of the animals from each group also received subcutaneous injections of PTH (60 μg/kg, three times a week) for 12 weeks.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

  2. 04AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH plus ZA improved peri-implant bone healing compared with control.

    In plain wordsIn rats, PTH plus ZA improved bone healing around implants compared with control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeri-implant bone healing with ZA
    Study

    ratn: not reported in source

    ovariectomized rats with tibial implants
    Comparator
    Control
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    All treatments promoted bone healing around implant compared to control, but PTH+ZA treatment showed significantly stronger effects than PTH or ZA alone in histological, micro-CT, and biomechanical tests.
    2 context sentences
    Summary · context
    The effect of human parathyroid hormone 1-34 (PTH) and zoledronic acid (ZA) alone or in combination on bone healing in osteoporotic settings was tested using implants inserted in tibiae of ovariectomized (OVX) rats.
    Summary · context
    Subsequently, half of the animals from each group also received subcutaneous injections of PTH (60 μg/kg, three times a week) for 12 weeks.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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