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Study · Animal study (in vivo) · sheep · 2013

2 results

Peri-pubertal gonadotropin-releasing hormone analog treatment affects hippocampus gene expression without changing spatial orientation in young sheep.

Nuruddin S, Wojniusz S, Ropstad E, Krogenæs A, Evans NP, Robinson JE, Solbakk AK, Amiry-Moghaddam M, Haraldsen IR

Behavioural brain research22 Dec 2012Cited by 15 (Europe PMC)

PMID23266521 (opens in a new tab)DOI10.1016/j.bbr.2012.12.027 (opens in a new tab)PepBankPUB-23266521
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, goserelin had no significant effect on spatial orientation compared with untreated lambs.

    In plain wordsIn sheep, goserelin did not significantly change spatial orientation compared with untreated lambs.

    Peptide
    Goserelin
    Outcome
    No significant changeSpatial orientation
    Study

    Sheepn = 30

    Peri-pubertal lambs
    Comparator
    Untreated lambs
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Every 4th week · Beginning before puberty until 50 weeks of ageAs given in this study (Sheep).

    Source sentences

    Summary
    The treatment had no significant effect on spatial orientation.
    1 context sentence
    Summary · context
    The study was conducted with 30 same-sex twin lambs, half of which were treated with the GnRH analog (GnRHa) goserelin acetate every 4th week, beginning before puberty, until 50 weeks of age.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In sheep, goserelin was associated with significant sex- and hemisphere-specific changes in hippocampal mRNA expression for some studied genes.

    In plain wordsIn sheep, goserelin was linked to sex- and hemisphere-specific hippocampal gene expression changes compared with untreated lambs.

    Peptide
    Goserelin
    Outcome
    Direction not reportedHippocampal mRNA expression
    Study

    Sheepn: not reported in source

    Peri-pubertal lambs
    Comparator
    Untreated lambs
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Every 4th week · Beginning before puberty until 50 weeks of ageAs given in this study (Sheep).

    Source sentences

    Summary
    GnRHa treatment was associated with significant sex- and hemisphere specific changes in mRNA expression for some of the genes studied.
    1 context sentence
    Summary · context
    The study was conducted with 30 same-sex twin lambs, half of which were treated with the GnRH analog (GnRHa) goserelin acetate every 4th week, beginning before puberty, until 50 weeks of age.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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