Skip to content

Study · Animal study (in vivo) · rat · 2013

6 results

The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model.

Pulman KG, Smith M, Mengozzi M, Ghezzi P, Dilley A

Neuroscience20 Dec 2012Cited by 27 (Europe PMC)

PMID23262243 (opens in a new tab)DOI10.1016/j.neuroscience.2012.12.022 (opens in a new tab)PepBankPUB-23262243
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with neuritis, ARA290 at 30 μg/kg prevented the development of mechanical allodynia compared with vehicle.

    In plain wordsIn rats with nerve inflammation, ARA290 at 30 μg/kg stopped pain from light touch from developing, compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMechanical allodynia, 30 μg/kg
    Study

    ratn = 11

    Neuritis model
    Comparator
    Saline vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    30 μg/kg · intraperitoneal · Daily from day 1 post surgeryAs given in this study (rat).

    Source sentences

    Summary
    Treatment with either 30 (n=11) or 120 μg/kg ARA290 (n=9) prevented the development of mechanical allodynia.
    2 context sentences
    Summary · context
    Vehicle-treated neuritis animals (n=20) developed signs of mechanical allodynia and heat hyperalgesia that reached a maximum on day 4 and 3 of testing, respectively.
    Summary · context
    Following neuritis induction, 30 or 120 μg/kg ARA290 or saline vehicle was injected intraperitoneally into rats daily from day 1 post surgery.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with neuritis, ARA290 at 120 μg/kg prevented the development of mechanical allodynia compared with vehicle.

    In plain wordsIn rats with nerve inflammation, ARA290 at 120 μg/kg stopped pain from light touch from developing, compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMechanical allodynia, 120 μg/kg
    Study

    ratn = 9

    Neuritis model
    Comparator
    Saline vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    120 μg/kg · intraperitoneal · Daily from day 1 post surgeryAs given in this study (rat).

    Source sentences

    Summary
    Treatment with either 30 (n=11) or 120 μg/kg ARA290 (n=9) prevented the development of mechanical allodynia.
    2 context sentences
    Summary · context
    Vehicle-treated neuritis animals (n=20) developed signs of mechanical allodynia and heat hyperalgesia that reached a maximum on day 4 and 3 of testing, respectively.
    Summary · context
    Following neuritis induction, 30 or 120 μg/kg ARA290 or saline vehicle was injected intraperitoneally into rats daily from day 1 post surgery.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with neuritis, ARA290 did not significantly affect heat hyperalgesia.

    In plain wordsIn rats with nerve inflammation, ARA290 did not clearly change extra sensitivity to heat.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeHeat hyperalgesia
    Study

    ratn: not reported in source

    Neuritis model
    Comparator
    Saline vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    30 and 120 μg/kg · intraperitoneal · Daily from day 1 post surgeryAs given in this study (rat).

    Source sentences

    Summary
    However, ARA290 did not significantly affect heat hyperalgesia.
    1 context sentence
    Summary · context
    Following neuritis induction, 30 or 120 μg/kg ARA290 or saline vehicle was injected intraperitoneally into rats daily from day 1 post surgery.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with neuritis, there was no significant difference between the effects of 30 and 120 μg/kg ARA290 on mechanical allodynia.

    In plain wordsIn rats with nerve inflammation, the 30 and 120 μg/kg doses of ARA290 worked about the same on pain from light touch.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeMechanical allodynia, dose comparison
    Study

    ratn: not reported in source

    Neuritis model
    Comparator
    30 versus 120 μg/kg
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    30 and 120 μg/kg · intraperitoneal · Daily from day 1 post surgeryAs given in this study (rat).

    Source sentences

    Summary
    There was no significant difference between the effects of each drug dose (p<0.05, unpaired t test comparing area under the curve for mechanical allodynia).
    1 context sentence
    Summary · context
    Following neuritis induction, 30 or 120 μg/kg ARA290 or saline vehicle was injected intraperitoneally into rats daily from day 1 post surgery.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with neuritis, CCL2 mRNA levels in the nerve and Gelfoam were not significantly different after ARA290 at 120 μg/kg compared with vehicle.

    In plain wordsIn rats with nerve inflammation, ARA290 did not change levels of the inflammation signal CCL2, compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeCCL2 mRNA in nerve and Gelfoam
    Study

    ratn: not reported in source

    Neuritis model
    Comparator
    Saline vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    120 μg/kg · intraperitoneal · Daily from day 1 post surgeryAs given in this study (rat).

    Source sentences

    Summary
    The levels of CCL2 and TNF-α mRNA in the nerve and Gelfoam were not significantly different following 120 μg/kg ARA290 treatment (n=3-7) compared to vehicle-treated animals (n=3-7; p=0.24; unpaired t tests).
    1 context sentence
    Summary · context
    Following neuritis induction, 30 or 120 μg/kg ARA290 or saline vehicle was injected intraperitoneally into rats daily from day 1 post surgery.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with neuritis, TNF-α mRNA levels in the nerve and Gelfoam were not significantly different after ARA290 at 120 μg/kg compared with vehicle.

    In plain wordsIn rats with nerve inflammation, ARA290 did not change levels of the inflammation signal TNF-α, compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeTNF-α mRNA in nerve and Gelfoam
    Study

    ratn: not reported in source

    Neuritis model
    Comparator
    Saline vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    120 μg/kg · intraperitoneal · Daily from day 1 post surgeryAs given in this study (rat).

    Source sentences

    Summary
    The levels of CCL2 and TNF-α mRNA in the nerve and Gelfoam were not significantly different following 120 μg/kg ARA290 treatment (n=3-7) compared to vehicle-treated animals (n=3-7; p=0.24; unpaired t tests).
    1 context sentence
    Summary · context
    Following neuritis induction, 30 or 120 μg/kg ARA290 or saline vehicle was injected intraperitoneally into rats daily from day 1 post surgery.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.