Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy.

Hsieh TC, Pastuszak AW, Hwang K, Lipshultz LI

The Journal of urology20 Dec 2012Cited by 69 (Europe PMC)

PMID23260550DOI10.1016/j.juro.2012.09.043PepBankPUB-23260550

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

01HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome
In hypogonadal men receiving testosterone replacement with hCG, mean serum testosterone rose from 207.2 to 1,055.5 ng/dl.
In plain wordsIn hypogonadal men, testosterone replacement with hCG was linked to blood testosterone rising from 207.2 to 1,055.5 ng/dl.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTotal testosterone
Study
n = 26
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Mean serum testosterone
207.2 ng/dl
Before testosterone replacement with hCG
Mean serum testosterone
1055.5 ng/dl
During testosterone replacement with hCG
p value for mean serum testosterone before versus during treatment
< 0.0001 p value
Before versus during testosterone replacement with hCG
Source sentences
Summary
Mean serum hormone levels before vs during treatment were testosterone 207.2 vs 1,055.5 ng/dl (p <0.0001), free testosterone 8.1 vs 20.4 pg/ml (p = 0.02) and estradiol 2.2 vs 3.7 pg/ml (p = 0.11).
4 context sentences(design, population, supporting numbers)
Summary · context
We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin.
Summary · context
Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day.
Summary · context
A total of 26 men with a mean age of 35.9 years were included in the study.
Summary · context
Mean followup was 6.2 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-2326055001
02HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome
In hypogonadal men receiving testosterone replacement with hCG, mean free testosterone rose from 8.1 to 20.4 pg/ml.
In plain wordsIn hypogonadal men, testosterone replacement with hCG was linked to free testosterone rising from 8.1 to 20.4 pg/ml.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseFree testosterone
Study
n = 26
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Mean free testosterone
8.1 pg/ml
Before testosterone replacement with hCG
Mean free testosterone
20.4 pg/ml
During testosterone replacement with hCG
p value for mean free testosterone before versus during treatment
0.02 p value
Before versus during testosterone replacement with hCG
Source sentences
Summary
Mean serum hormone levels before vs during treatment were testosterone 207.2 vs 1,055.5 ng/dl (p <0.0001), free testosterone 8.1 vs 20.4 pg/ml (p = 0.02) and estradiol 2.2 vs 3.7 pg/ml (p = 0.11).
4 context sentences(design, population, supporting numbers)
Summary · context
We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin.
Summary · context
Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day.
Summary · context
A total of 26 men with a mean age of 35.9 years were included in the study.
Summary · context
Mean followup was 6.2 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-2326055002
03HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome
In hypogonadal men, testosterone replacement with hCG did not significantly change estradiol (2.2 versus 3.7 pg/ml, p = 0.11).
In plain wordsIn hypogonadal men, testosterone replacement with hCG did not significantly change estradiol compared with baseline.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeEstradiol
Study
n = 26
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Mean estradiol
2.2 pg/ml
Before testosterone replacement with hCG
Mean estradiol
3.7 pg/ml
During testosterone replacement with hCG
p value for mean estradiol before versus during treatment
0.11 p value
Before versus during testosterone replacement with hCG
Source sentences
Summary
Mean serum hormone levels before vs during treatment were testosterone 207.2 vs 1,055.5 ng/dl (p <0.0001), free testosterone 8.1 vs 20.4 pg/ml (p = 0.02) and estradiol 2.2 vs 3.7 pg/ml (p = 0.11).
4 context sentences(design, population, supporting numbers)
Summary · context
We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin.
Summary · context
Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day.
Summary · context
A total of 26 men with a mean age of 35.9 years were included in the study.
Summary · context
Mean followup was 6.2 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-2326055003
04HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome
In hypogonadal men receiving testosterone replacement with hCG, testosterone formulation had no observed impact on semen parameters.
In plain wordsIn hypogonadal men receiving testosterone with hCG, semen measures did not differ by testosterone formulation.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeSemen parameters by testosterone formulation
Study
n = 26
Comparator
Other testosterone formulation
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Men treated with injectable testosterone
19 men
Testosterone formulation comparison, concomitant hCG
Men treated with transdermal testosterone gel
7 men
Testosterone formulation comparison, concomitant hCG
Source sentences
Summary
No impact on semen parameters was observed as a function of testosterone formulation.
Summary
Of the men 19 were treated with injectable testosterone and 7 were treated with transdermal gel.
4 context sentences(design, population, supporting numbers)
Summary · context
We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin.
Summary · context
Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day.
Summary · context
A total of 26 men with a mean age of 35.9 years were included in the study.
Summary · context
Mean followup was 6.2 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-2326055008
05HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome
No hypogonadal man developed azoospermia during testosterone replacement with hCG.
In plain wordsNo hypogonadal man lost all sperm in his semen during testosterone replacement with hCG.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeAzoospermia
Study
n = 26
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
No patient became azoospermic during concomitant testosterone replacement and human chorionic gonadotropin therapy.
4 context sentences(design, population, supporting numbers)
Summary · context
We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin.
Summary · context
Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day.
Summary · context
A total of 26 men with a mean age of 35.9 years were included in the study.
Summary · context
Mean followup was 6.2 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-2326055009
06HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome
During testosterone replacement with hCG, nine of 26 men contributed to pregnancy with their partner.
In plain wordsDuring testosterone replacement with hCG, nine of 26 men contributed to a pregnancy with their partner.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicablePartner pregnancy
Study
n = 26
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Men contributing to pregnancy with their partner
9 men
During testosterone replacement with hCG, followup
Source sentences
Summary
Nine of 26 men contributed to pregnancy with the partner during followup.
4 context sentences(design, population, supporting numbers)
Summary · context
We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin.
Summary · context
Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day.
Summary · context
A total of 26 men with a mean age of 35.9 years were included in the study.
Summary · context
Mean followup was 6.2 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-2326055010
07HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome
In hypogonadal men, semen parameters did not differ during testosterone replacement with hCG over greater than 1 year of followup.
In plain wordsIn hypogonadal men, semen measures did not differ from baseline during testosterone replacement with hCG.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeSemen parameters over follow-up
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Semen volume before treatment
2.9 ml
Before testosterone replacement with hCG, comparison with during followup
Sperm density before treatment
35.2 million per ml
Before testosterone replacement with hCG, comparison with during followup
Sperm motility before treatment
49%
Before testosterone replacement with hCG, comparison with during followup
Sperm forward progression before treatment
2.3 not stated
Before testosterone replacement with hCG, comparison with during followup
Source sentences
Summary
No differences in semen parameters were observed during greater than 1 year of followup.
5 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment semen parameters were volume 2.9 ml, density 35.2 million per ml, motility 49.0% and forward progression 2.3.
Summary · context
We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin.
Summary · context
Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day.
Summary · context
A total of 26 men with a mean age of 35.9 years were included in the study.
Summary · context
Mean followup was 6.2 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-2326055004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.