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Study · Measured the body's own peptide · 2013

5 results

Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters.

Lawson EA, Ackerman KE, Estella NM, Guereca G, Pierce L, Sluss PM, Bouxsein ML, Klibanski A, Misra M

European journal of endocrinology20 Feb 2013Cited by 46 (Europe PMC)

PMID23258269 (opens in a new tab)PMCIDPMC3679669 (opens in a new tab)DOI10.1530/eje-12-0869 (opens in a new tab)PepBankPUB-23258269
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In young females, nocturnal serum oxytocin levels were lower in amenorrheic athletes and in eumenorrheic athletes than in nonathletes.

    In plain wordsIn young women, the body's own oxytocin at night was lower in athletes than in non-athletes.

    Peptide
    Oxytocin
    Outcome
    DecreaseNocturnal oxytocin secretion
    Study

    n = 45

    Comparator
    Nonathletes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Nocturnal oxytocin levels were lower in AA and EA than in NA.
    1 context sentence
    Summary · context
    Cross-sectional study of 45 females, 14-21 years (15 amenorrheic athletes (AA), 15 eumenorrheic athletes (EA), and 15 nonathletes (NA)), of comparable bone age and BMI.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In young females, midnight and 0700 h oxytocin levels did not differ between amenorrheic athletes, eumenorrheic athletes and nonathletes.

    In plain wordsIn young women, the body's own oxytocin at midnight and early morning did not differ between athletes and non-athletes.

    Peptide
    Oxytocin
    Outcome
    No significant changeMidnight and 0700 h oxytocin levels
    Study

    n = 45

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Midnight and 0700  h oxytocin levels did not differ between groups.
    1 context sentence
    Summary · context
    Cross-sectional study of 45 females, 14-21 years (15 amenorrheic athletes (AA), 15 eumenorrheic athletes (EA), and 15 nonathletes (NA)), of comparable bone age and BMI.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In amenorrheic athletes, nocturnal oxytocin correlated strongly with trabecular and cortical bone microarchitecture, particularly at the non-weight-bearing radius.

    In plain wordsIn athletes with missing periods, higher natural oxytocin at night was linked to better bone structure, mostly in the forearm.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of nocturnal oxytocin with bone microarchitecture in amenorrheic athletes
    Study

    n = 15

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In AA, nocturnal oxytocin correlated strongly with trabecular and cortical microarchitecture, particularly at the non-weight-bearing radius.
    1 context sentence
    Summary · context
    Cross-sectional study of 45 females, 14-21 years (15 amenorrheic athletes (AA), 15 eumenorrheic athletes (EA), and 15 nonathletes (NA)), of comparable bone age and BMI.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In amenorrheic athletes, nocturnal oxytocin accounted for a substantial portion of the variability in bone microarchitectural and strength parameters in regression models.

    In plain wordsIn athletes with missing periods, the body's own oxytocin explained a large part of the differences in bone structure and strength.

    Peptide
    Oxytocin
    Outcome
    Not applicableShare of variability in bone microarchitecture and strength explained by oxytocin
    Study

    n = 15

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In regression models that include known predictors of microarchitecture in AA, oxytocin accounted for a substantial portion of the variability in microarchitectural and strength parameters.
    1 context sentence
    Summary · context
    Cross-sectional study of 45 females, 14-21 years (15 amenorrheic athletes (AA), 15 eumenorrheic athletes (EA), and 15 nonathletes (NA)), of comparable bone age and BMI.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In young females, after control for estradiol, nocturnal oxytocin remained lower in amenorrheic athletes than in nonathletes.

    In plain wordsIn young women, the body's own oxytocin at night stayed lower in athletes with missing periods, even after accounting for estradiol.

    Peptide
    Oxytocin
    Outcome
    DecreaseNocturnal oxytocin in amenorrheic athletes versus nonathletes after estradiol adjustment
    Study

    n: not reported in source

    Comparator
    Nonathletes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    After controlling for estradiol, the difference in nocturnal oxytocin between AA and NA remained significant.
    1 context sentence
    Summary · context
    Cross-sectional study of 45 females, 14-21 years (15 amenorrheic athletes (AA), 15 eumenorrheic athletes (EA), and 15 nonathletes (NA)), of comparable bone age and BMI.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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