PTH (1-34), but not strontium ranelate counteract loss of trabecular thickness and bone strength in disuse osteopenic rats.

Brüel A, Vegger JB, Raffalt AC, Andersen JE, Thomsen JS

Bone11 Dec 2012Cited by 25 (Europe PMC)

PMID23246791DOI10.1016/j.bone.2012.11.037PepBankPUB-23246791

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH alone increased trabecular bone formation rate versus BTX alone.
In plain wordsIn immobilized rats, PTH increased trabecular bone formation compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular bone formation rate
Study
ratn = 24
Botox-induced hindlimb immobilization in female Wistar rats
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 μg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).
Measurements
Bone formation rate increase
4 fold
versus BTX
Source sentences
Summary
PTH alone counteracted immobilization-induced losses in trabecular (4-fold increase vs. BTX) and periosteal (5-fold increase vs. BTX) bone formation rate, trabecular thickness (+25% vs. BTX) and femoral neck strength (+24% vs. BTX).
4 context sentences(design, population, supporting numbers)
Summary · context
Immobilization was induced by injecting 4IU Botox (BTX) into the muscles of the right hind limb.
Summary · context
Seventy-two female Wistar rats, 3-months-old, were divided into the following groups: Baseline, Controls, BTX, BTX+PTH, BTX+SrR, and BTX+PTH+SrR (n=12 in each group).
Summary · context
PTH was given as injections (SC) at a dosage of 60μg/kg/d, and SrR as 900mg/kg/d in the diet.
Summary · context
The experiment lasted for 4weeks.
Report a problemFND-2324679101
02AnimalAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH alone increased periosteal bone formation rate versus BTX alone.
In plain wordsIn immobilized rats, PTH increased periosteal bone formation compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePeriosteal bone formation rate
Study
ratn = 24
Botox-induced hindlimb immobilization in female Wistar rats
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 μg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).
Measurements
Bone formation rate increase
5 fold
versus BTX
Source sentences
Summary
PTH alone counteracted immobilization-induced losses in trabecular (4-fold increase vs. BTX) and periosteal (5-fold increase vs. BTX) bone formation rate, trabecular thickness (+25% vs. BTX) and femoral neck strength (+24% vs. BTX).
4 context sentences(design, population, supporting numbers)
Summary · context
Immobilization was induced by injecting 4IU Botox (BTX) into the muscles of the right hind limb.
Summary · context
Seventy-two female Wistar rats, 3-months-old, were divided into the following groups: Baseline, Controls, BTX, BTX+PTH, BTX+SrR, and BTX+PTH+SrR (n=12 in each group).
Summary · context
PTH was given as injections (SC) at a dosage of 60μg/kg/d, and SrR as 900mg/kg/d in the diet.
Summary · context
The experiment lasted for 4weeks.
Report a problemFND-2324679102
03AnimalAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH alone increased trabecular thickness versus BTX alone.
In plain wordsIn immobilized rats, PTH increased trabecular thickness compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular thickness
Study
ratn = 24
Botox-induced hindlimb immobilization in female Wistar rats
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 μg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).
Measurements
Trabecular thickness increase
25%
versus BTX
Source sentences
Summary
PTH alone counteracted immobilization-induced losses in trabecular (4-fold increase vs. BTX) and periosteal (5-fold increase vs. BTX) bone formation rate, trabecular thickness (+25% vs. BTX) and femoral neck strength (+24% vs. BTX).
4 context sentences(design, population, supporting numbers)
Summary · context
Immobilization was induced by injecting 4IU Botox (BTX) into the muscles of the right hind limb.
Summary · context
Seventy-two female Wistar rats, 3-months-old, were divided into the following groups: Baseline, Controls, BTX, BTX+PTH, BTX+SrR, and BTX+PTH+SrR (n=12 in each group).
Summary · context
PTH was given as injections (SC) at a dosage of 60μg/kg/d, and SrR as 900mg/kg/d in the diet.
Summary · context
The experiment lasted for 4weeks.
Report a problemFND-2324679103
04AnimalAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH alone increased femoral neck strength versus BTX alone.
In plain wordsIn immobilized rats, PTH increased femoral neck strength compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral neck strength
Study
ratn = 24
Botox-induced hindlimb immobilization in female Wistar rats
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 μg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).
Measurements
Femoral neck strength increase
24%
versus BTX
Source sentences
Summary
PTH alone counteracted immobilization-induced losses in trabecular (4-fold increase vs. BTX) and periosteal (5-fold increase vs. BTX) bone formation rate, trabecular thickness (+25% vs. BTX) and femoral neck strength (+24% vs. BTX).
4 context sentences(design, population, supporting numbers)
Summary · context
Immobilization was induced by injecting 4IU Botox (BTX) into the muscles of the right hind limb.
Summary · context
Seventy-two female Wistar rats, 3-months-old, were divided into the following groups: Baseline, Controls, BTX, BTX+PTH, BTX+SrR, and BTX+PTH+SrR (n=12 in each group).
Summary · context
PTH was given as injections (SC) at a dosage of 60μg/kg/d, and SrR as 900mg/kg/d in the diet.
Summary · context
The experiment lasted for 4weeks.
Report a problemFND-2324679104

Studies that did not test the peptide alone1

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In immobilized rats, combined PTH and strontium ranelate showed no additive effect over individual treatments.
In plain wordsIn immobilized rats, combined PTH and strontium ranelate showed no extra effect over individual treatments.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeAdditive combination effect
Study
ratn: not reported in source
Botox-induced hindlimb immobilization in female Wistar rats
Comparator
Individual PTH or SrR treatments
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Finally, no additive effect was found when PTH and SrR treatments were combined.
4 context sentences(design, population, supporting numbers)
Summary · context
Immobilization was induced by injecting 4IU Botox (BTX) into the muscles of the right hind limb.
Summary · context
Seventy-two female Wistar rats, 3-months-old, were divided into the following groups: Baseline, Controls, BTX, BTX+PTH, BTX+SrR, and BTX+PTH+SrR (n=12 in each group).
Summary · context
PTH was given as injections (SC) at a dosage of 60μg/kg/d, and SrR as 900mg/kg/d in the diet.
Summary · context
The experiment lasted for 4weeks.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2324679105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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