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Study · Animal study (in vivo) · rat · 2012

2 results

Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.

Arutjunyan A, Kozina L, Milyutina Y, Korenevsky A, Stepanov M, Arutyunov V

Current aging science1 Dec 2012Cited by 1 (Europe PMC)

PMID23237594 (opens in a new tab)DOI10.2174/1874609811205030003 (opens in a new tab)PepBankPUB-23237594
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats with DMH-disturbed circadian rhythms, epitalon was more effective in the median eminence with arcuate nuclei and prevented the xenobiotic-caused disturbance of the diurnal dopamine rhythm.

    In plain wordsIn female rats with disturbed body rhythms, epitalon prevented the disturbance of the daily dopamine pattern in one brain area.

    Peptide
    Epitalon
    Outcome
    Direction not reportedDiurnal dopamine rhythm in median eminence with arcuate nuclei
    Study

    ratn: not reported in source

    Female rats with 1,2-dimethylhydrazine (DMH) model of premature reproductive aging
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epitalon (Ala-Glu-Asp-Gly) proved to be more effective in ME-Arc. This peptide prevents the xenobiotic caused disturbance of DA diurnal rhythm, keeping this metabolite low at 5 o'clock (CT) with it having increased by 11 o'clock (CT).

Studies that did not test the peptide alone1

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

  1. 02AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome

    In female rats with DMH-disturbed circadian rhythms, melatonin and the pineal peptides epithalamine and epitalon exerted a correcting influence on the diurnal dynamics of norepinephrine in the medial preoptic area; effects were not reported separately.

    In plain wordsIn female rats with disturbed body rhythms, epitalon with other pineal substances corrected the daily pattern of norepinephrine in one brain area.

    Peptide
    Epitalon
    Outcome
    Direction not reportedDiurnal dynamics of norepinephrine in the medial preoptic area
    Study

    ratn: not reported in source

    Female rats with 1,2-dimethylhydrazine (DMH) model of premature reproductive aging
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    We have shown that melatonin and the pineal gland peptides (epithalamine and epitalon) exert a correcting influence on the diurnal dynamics of norepinephrine (NE) in the medial preoptic area (MPA) and of dopamine (DA) in the median eminence with arcuate nuclei (ME-Arc) disturbed by single administra…

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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