In male rats, an oxytocin receptor antagonist given into the brain reduced clavulanic acid-induced penile erection and yawning by about 55%.
In plain wordsIn male rats, blocking oxytocin receptors reduced the penile erection and yawning that clavulanic acid caused, by about 55%.
- Peptide
- Oxytocin
- Outcome
- DecreaseClavulanic acid-induced penile erection and yawning after oxytocin receptor blockade
- Study
ratn: not reported in source
male rats given clavulanic acid- Outcome group
- Sexual function · Reproductive and sexual health
Measurements
- Reduction of clavulanic acid responses
- ≈ 55%
- oxytocin receptor antagonist 2 µg/rat ICV
Source sentences
Clavulanic acid responses were reduced by about 55% by haloperidol, a dopamine D2 receptor antagonist (0.1mg/kg IP), and by d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin, an oxytocin receptor antagonist (2 μg/rat ICV), both given 15 min before clavulanic acid.
1 context sentence(design, population, supporting numbers)
The beta-lactamase inhibitor clavulanic acid induced penile erection and yawning in a dose dependent manner when given intraperitoneally (IP, 0.05-5mg/kg), perorally (OS, 0.1-5mg/kg) and intracereboventricularly (ICV, 0.01-5 μg/rat) to male rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.