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Study · Animal study (in vivo) · mouse · 2013

3 results

Neurotrophic peptides, ADNF-9 and NAP, prevent alcohol-induced apoptosis at midgestation in fetal brains of C57BL/6 mouse.

Sari Y, Weedman JM, Nkrumah-Abrokwah M

Journal of molecular neuroscience : MN16 Nov 2012Cited by 5 (Europe PMC)

PMID23229836 (opens in a new tab)PMCIDPMC3534902 (opens in a new tab)DOI10.1007/s12031-012-9921-3 (opens in a new tab)PepBankPUB-23229836
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In fetal mice, NAP significantly prevented alcohol-induced brain weight reduction.

    In plain wordsIn mice, NAP prevented fetal brain weight loss compared with alcohol exposure alone.

    Peptide
    Davunetide
    Outcome
    IncreaseFetal brain weight
    Study

    mousen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without NAP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1.5 mg/kg · intraperitoneal · E7 to E15As given in this study (mouse).

    Source sentences

    Summary
    Our results show that NAP and ADNF-9 significantly prevented alcohol-induced weight reduction of fetal brains.
    2 context sentences
    Summary · context
    We used an established fetal alcohol exposure mouse model.
    Summary · context
    ADNF-9 or NAP was administered daily from E7 to E15 alongside PF or ALC liquid diet exposure.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In fetal mice, NAP significantly prevented the alcohol-induced increase in TUNEL-positive cells in the cingulate cortex primordium.

    In plain wordsIn mice, NAP prevented increased cell death markers in the cingulate cortex compared with alcohol exposure alone.

    Peptide
    Davunetide
    Outcome
    DecreaseTUNEL-positive cells in cingulate cortex primordium
    Study

    mousen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without NAP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1.5 mg/kg · intraperitoneal · E7 to E15As given in this study (mouse).

    Source sentences

    Summary
    Apoptosis was determined by TUNEL staining; NAP or ADNF-9 administration alongside alcohol exposure significantly prevented alcohol-induced increase in TUNEL-positive cells in primordium of the cingulate cortex and ganglionic eminence.
    2 context sentences
    Summary · context
    We used an established fetal alcohol exposure mouse model.
    Summary · context
    ADNF-9 or NAP was administered daily from E7 to E15 alongside PF or ALC liquid diet exposure.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In fetal mice, NAP significantly prevented the alcohol-induced increase in TUNEL-positive cells in the ganglionic eminence.

    In plain wordsIn mice, NAP prevented increased cell death markers in the ganglionic eminence compared with alcohol exposure alone.

    Peptide
    Davunetide
    Outcome
    DecreaseTUNEL-positive cells in ganglionic eminence
    Study

    mousen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without NAP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1.5 mg/kg · intraperitoneal · E7 to E15As given in this study (mouse).

    Source sentences

    Summary
    Apoptosis was determined by TUNEL staining; NAP or ADNF-9 administration alongside alcohol exposure significantly prevented alcohol-induced increase in TUNEL-positive cells in primordium of the cingulate cortex and ganglionic eminence.
    2 context sentences
    Summary · context
    We used an established fetal alcohol exposure mouse model.
    Summary · context
    ADNF-9 or NAP was administered daily from E7 to E15 alongside PF or ALC liquid diet exposure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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