Neuroprotective peptides influence cytokine and chemokine alterations in a model of fetal alcohol syndrome.

Roberson R, Kuddo T, Benassou I, Abebe D, Spong CY

American journal of obstetrics and gynecology5 Oct 2012Cited by 11 (Europe PMC)

PMID23174390DOI10.1016/j.ajog.2012.10.005PepBankPUB-23174390

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Davunetide.

01AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, alcohol plus NAP plus SAL produced undetectable IL-6, similar to controls (P < .003).
In plain wordsIn mouse embryos, alcohol plus NAP plus SAL produced undetectable IL-6 versus detectable levels with alcohol alone, similar to controls.
Peptide
Davunetide
Outcome
DecreaseIL-6 at six hours
Study
mousen: not reported in source
fetal alcohol syndrome model
Comparator
Alcohol alone
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Embryos exposed to alcohol plus NAP plus SAL had undetectable IL-6 and KC (both P < .003), similar to the controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439001
02AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, alcohol plus NAP plus SAL produced undetectable KC, similar to controls (P < .003).
In plain wordsIn mouse embryos, alcohol plus NAP plus SAL produced undetectable KC versus detectable levels with alcohol alone, similar to controls.
Peptide
Davunetide
Outcome
DecreaseKC at six hours
Study
mousen: not reported in source
fetal alcohol syndrome model
Comparator
Alcohol alone
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Embryos exposed to alcohol plus NAP plus SAL had undetectable IL-6 and KC (both P < .003), similar to the controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439002
03AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, NAP plus SAL prevented the alcohol-induced increase in G-CSF.
In plain wordsIn mouse embryos, NAP plus SAL prevented increased G-CSF compared with alcohol alone.
Peptide
Davunetide
Outcome
DecreaseG-CSF increase
Study
mousen: not reported in source
fetal alcohol syndrome model
Comparator
Alcohol alone
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Alcohol exposure resulted in a significant increase of granulocyte colony-stimulating factor (G-CSF) (P < .003) as compared with controls, and treatment with NAP plus SAL prevented the alcohol-induced increase.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439003
04AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, alcohol plus NAP plus SAL did not completely ameliorate the alcohol-associated IL-13 decrease after 6 hours.
In plain wordsIn mouse embryos, NAP plus SAL did not fully correct the IL-13 decrease after alcohol exposure.
Peptide
Davunetide
Outcome
Direction not reportedIL-13 decrease
Study
mousen: not reported in source
fetal alcohol syndrome model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
IL-13 and IL-1β were decreased 6 hours after alcohol exposure, and exposure to alcohol plus NAP plus SAL did not completely ameliorate the decrease.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439004
05AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, alcohol plus NAP plus SAL did not completely ameliorate the alcohol-associated IL-1β decrease after 6 hours.
In plain wordsIn mouse embryos, NAP plus SAL did not fully correct the IL-1β decrease after alcohol exposure.
Peptide
Davunetide
Outcome
Direction not reportedIL-1β decrease
Study
mousen: not reported in source
fetal alcohol syndrome model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
IL-13 and IL-1β were decreased 6 hours after alcohol exposure, and exposure to alcohol plus NAP plus SAL did not completely ameliorate the decrease.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439005
06AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, cytokine and chemokine alterations were no longer present at E18, including after alcohol plus NAP plus SAL.
In plain wordsIn mouse embryos, cytokine and chemokine changes were absent at E18, including in the NAP plus SAL group.
Peptide
Davunetide
Outcome
Direction not reportedCytokine and chemokine alterations at E18
Study
mousen: not reported in source
fetal alcohol syndrome model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
At E18, 10 days after exposure, these alterations were no longer present.
3 context sentences(design, population, supporting numbers)
Summary · context
IL-13 and IL-1β were decreased 6 hours after alcohol exposure, and exposure to alcohol plus NAP plus SAL did not completely ameliorate the decrease.
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439006
07AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, RANTES was undetectable at both time points in all groups, including alcohol plus NAP plus SAL.
In plain wordsIn mouse embryos, RANTES was undetectable at both times in all groups, including the NAP plus SAL group.
Peptide
Davunetide
Outcome
Not applicableRANTES detectability
Study
mousen: not reported in source
fetal alcohol syndrome model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Several analytes (regulated upon activation, normal T cell expressed, and secreted, tumor necrosis factor-α, interferon-γ, and IL-4) were not detectable at either time point in any of the groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439007
08AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, tumor necrosis factor-α was undetectable at both time points in all groups, including alcohol plus NAP plus SAL.
In plain wordsIn mouse embryos, tumor necrosis factor-α was undetectable at both times in all groups, including the NAP plus SAL group.
Peptide
Davunetide
Outcome
Not applicableTNF-α detectability
Study
mousen: not reported in source
fetal alcohol syndrome model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Several analytes (regulated upon activation, normal T cell expressed, and secreted, tumor necrosis factor-α, interferon-γ, and IL-4) were not detectable at either time point in any of the groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439008
09AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, interferon-γ was undetectable at both time points in all groups, including alcohol plus NAP plus SAL.
In plain wordsIn mouse embryos, interferon-γ was undetectable at both times in all groups, including the NAP plus SAL group.
Peptide
Davunetide
Outcome
Not applicableInterferon-γ detectability
Study
mousen: not reported in source
fetal alcohol syndrome model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Several analytes (regulated upon activation, normal T cell expressed, and secreted, tumor necrosis factor-α, interferon-γ, and IL-4) were not detectable at either time point in any of the groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439009
10AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In mouse embryos, IL-4 was undetectable at both time points in all groups, including alcohol plus NAP plus SAL.
In plain wordsIn mouse embryos, IL-4 was undetectable at both times in all groups, including the NAP plus SAL group.
Peptide
Davunetide
Outcome
Not applicableIL-4 detectability
Study
mousen: not reported in source
fetal alcohol syndrome model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Several analytes (regulated upon activation, normal T cell expressed, and secreted, tumor necrosis factor-α, interferon-γ, and IL-4) were not detectable at either time point in any of the groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a well-characterized FAS model, timed, pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol plus peptides.
Summary · context
Embryos were evaluated at 2 time points: after 6 hours and 10 days later at E18.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2317439010

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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