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Study · Randomized controlled trial · n = 48 · 2013

3 results

The impact of oxytocin administration and maternal love withdrawal on event-related potential (ERP) responses to emotional faces with performance feedback.

Huffmeijer R, Alink LR, Tops M, Grewen KM, Light KC, Bakermans-Kranenburg MJ, van Ijzendoorn MH

Hormones and behavior15 Nov 2012Cited by 30 (Europe PMC)

PMID23159479 (opens in a new tab)DOI10.1016/j.yhbeh.2012.11.008 (opens in a new tab)PepBankPUB-23159479
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In 48 female students, VPP amplitudes were more positive after intranasal oxytocin than after placebo.

    In plain wordsIn female students, a brain signal linked to face processing was stronger after oxytocin spray than after placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseVertex positive potential (VPP) amplitude
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    16 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Vertex positive potential (VPP) and late positive potential (LPP) amplitudes were more positive after oxytocin compared to placebo administration.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled within-subjects design, we studied the effects of 16 IU of intranasal oxytocin on ERPs to pictures combining performance feedback with emotional facial expressions in 48 female undergraduate students.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In 48 female students, LPP amplitudes were more positive after intranasal oxytocin than after placebo.

    In plain wordsIn female students, a brain signal linked to attention was stronger after oxytocin spray than after placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseLate positive potential (LPP) amplitude
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    16 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Vertex positive potential (VPP) and late positive potential (LPP) amplitudes were more positive after oxytocin compared to placebo administration.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled within-subjects design, we studied the effects of 16 IU of intranasal oxytocin on ERPs to pictures combining performance feedback with emotional facial expressions in 48 female undergraduate students.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In 48 female students, oxytocin heightened processing of happy and disgusted faces, primarily in those reporting less maternal love withdrawal.

    In plain wordsIn female students, oxytocin spray raised processing of happy and disgusted faces, mostly in those reporting less love withdrawal from their mothers.

    Peptide
    Oxytocin
    Outcome
    IncreaseProcessing of happy and disgusted faces by love withdrawal
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    16 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin heightened processing of the happy and disgusted faces primarily for those reporting less love withdrawal.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled within-subjects design, we studied the effects of 16 IU of intranasal oxytocin on ERPs to pictures combining performance feedback with emotional facial expressions in 48 female undergraduate students.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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