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Study · Animal study (in vivo) · mouse and rat · 2012

5 results

[An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines].

Alekseeva SV, Kovalenko LP, Tallerova AV, Gudasheva TA, Durnev AD

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2012Cited by 1 (Europe PMC)

PMID23156084 (opens in a new tab)PepBankPUB-23156084
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Noopept significantly suppressed the inflammatory response to carrageenan.

    In plain wordsIn rats, Noopept reduced inflammation caused by carrageenan.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseCarrageenan inflammatory response
    Study

    ratsn: not reported in source

    Carrageenan-induced acute exudative inflammation in outbred rats
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1, 5, and 10 mg/kg · intraperitoneal · single administrationAs given in this study (rats).

    Source sentences

    Summary
    The administration of noopept led to a significant suppression of the inflammatory response to both carrageenan and Con A.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of noopept (dipeptide analog of piracetam) upon a single intraperitoneal (i.p.) administration at doses of 1, 5, and 10 mg/kg in comparison to the reference drug diclofenac (10 mg/kg, i.p.) have been studied on a model of acute exudative inflammation induced by carragee…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, Noopept significantly suppressed the inflammatory response to concanavalin A.

    In plain wordsIn mice, Noopept reduced inflammation caused by concanavalin A.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseConcanavalin A inflammatory response
    Study

    micen: not reported in source

    Concanavalin A-induced inflammation in CBA mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1, 5, and 10 mg/kg · intraperitoneal · single administrationAs given in this study (mice).

    Source sentences

    Summary
    The administration of noopept led to a significant suppression of the inflammatory response to both carrageenan and Con A.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of noopept (dipeptide analog of piracetam) upon a single intraperitoneal (i.p.) administration at doses of 1, 5, and 10 mg/kg in comparison to the reference drug diclofenac (10 mg/kg, i.p.) have been studied on a model of acute exudative inflammation induced by carragee…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with concanavalin A inflammation, Noopept reduced serum IL-6 by a factor of 1.8.

    In plain wordsIn mice with concanavalin A inflammation, Noopept reduced an inflammation marker called IL-6.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseSerum IL-6 after Con A
    Study

    micen: not reported in source

    Concanavalin A-induced inflammation in CBA mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mice).

    Measurements

    IL-6 reduction factor
    1.8 fold
    Noopept during Con A inflammation

    Source sentences

    Summary
    Noopept (5 mg/kg) reduced the level of IL-6 by a factor of 1.8 in the inflammatory response to Con A.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of noopept (dipeptide analog of piracetam) upon a single intraperitoneal (i.p.) administration at doses of 1, 5, and 10 mg/kg in comparison to the reference drug diclofenac (10 mg/kg, i.p.) have been studied on a model of acute exudative inflammation induced by carragee…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-exposed mice, a Noopept course significantly decreased serum IL-6.

    In plain wordsIn mice exposed to LPS, Noopept reduced an inflammation marker called IL-6.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseSerum IL-6 after LPS
    Study

    micen: not reported in source

    LPS model in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kg · intraperitoneal · 5 daysAs given in this study (mice).

    Source sentences

    Summary
    The course administration of noopept (5 mg/kg) significantly decreased the level of IL-6 and reduced by half the level of TNF-alpha.
    1 context sentence
    Summary · context
    The level of cytokines was studied on the lipopolysaccharide (LPS) model (single administration, 100 mg/kg, i.p.) with 5-day administration of noopept at a dose of 5 mg/kg (i.p., before endotoxin injection) in C57BL/6 mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-exposed mice, a Noopept course reduced serum TNF-alpha by half.

    In plain wordsIn mice exposed to LPS, Noopept halved an inflammation marker called TNF-alpha.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseSerum TNF-alpha after LPS
    Study

    micen: not reported in source

    LPS model in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kg · intraperitoneal · 5 daysAs given in this study (mice).

    Source sentences

    Summary
    The course administration of noopept (5 mg/kg) significantly decreased the level of IL-6 and reduced by half the level of TNF-alpha.
    1 context sentence
    Summary · context
    The level of cytokines was studied on the lipopolysaccharide (LPS) model (single administration, 100 mg/kg, i.p.) with 5-day administration of noopept at a dose of 5 mg/kg (i.p., before endotoxin injection) in C57BL/6 mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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