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Study · Animal study (in vivo) · mouse · 2013

12 results

Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease.

Ubhi K, Rockenstein E, Vazquez-Roque R, Mante M, Inglis C, Patrick C, Adame A, Fahnestock M, Doppler E, Novak P, Moessler H, Masliah E

Journal of neuroscience research14 Nov 2012Cited by 41 (Europe PMC)

PMID23152192 (opens in a new tab)DOI10.1002/jnr.23142 (opens in a new tab)PepBankPUB-23152192
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In hAPP transgenic mice, Cerebrolysin restored pro-NGF levels to values comparable to control, unlike elevated levels with saline.

    In plain wordsIn mice with an Alzheimer's disease model, Cerebrolysin restored pro-NGF levels to control values, unlike saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePro-NGF protein levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, CBL-treated hAPP tg mice showed levels of pro-NGF comparable to control and increased levels of mature NGF.
    2 context sentences
    Summary · context
    Immunoblot analysis demonstrated that levels of pro-NGF were increased in saline-treated hAPP tg mice.
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In hAPP transgenic mice, Cerebrolysin increased mature NGF levels.

    In plain wordsIn hAPP transgenic mice, mature NGF levels increased with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMature NGF protein levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, CBL-treated hAPP tg mice showed levels of pro-NGF comparable to control and increased levels of mature NGF.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In hAPP transgenic mice, Cerebrolysin increased hippocampal NGF immunoreactivity.

    In plain wordsIn hAPP transgenic mice, hippocampal NGF staining increased with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseHippocampal NGF immunoreactivity
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consistently with these results, immunohistochemical analysis demonstrated increased NGF immunoreactivity in the hippocampus of CBL-treated hAPP tg mice.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In the hAPP transgenic model, BDNF protein levels were unchanged with Cerebrolysin.

    In plain wordsIn hAPP transgenic mice, BDNF protein levels stayed unchanged with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeBDNF protein levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein levels of other neurotrophic factors, including BDNF, NT3, NT4, and CNTF, were unchanged. mRNA levels of NGF and other neurotrophins were also unchanged.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In the hAPP transgenic model, NT3 protein levels were unchanged with Cerebrolysin.

    In plain wordsIn hAPP transgenic mice, NT3 protein levels stayed unchanged with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeNT3 protein levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein levels of other neurotrophic factors, including BDNF, NT3, NT4, and CNTF, were unchanged. mRNA levels of NGF and other neurotrophins were also unchanged.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In the hAPP transgenic model, NT4 protein levels were unchanged with Cerebrolysin.

    In plain wordsIn hAPP transgenic mice, NT4 protein levels stayed unchanged with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeNT4 protein levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein levels of other neurotrophic factors, including BDNF, NT3, NT4, and CNTF, were unchanged. mRNA levels of NGF and other neurotrophins were also unchanged.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In the hAPP transgenic model, CNTF protein levels were unchanged with Cerebrolysin.

    In plain wordsIn hAPP transgenic mice, CNTF protein levels stayed unchanged with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeCNTF protein levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein levels of other neurotrophic factors, including BDNF, NT3, NT4, and CNTF, were unchanged. mRNA levels of NGF and other neurotrophins were also unchanged.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In the hAPP transgenic model, NGF mRNA levels were unchanged with Cerebrolysin.

    In plain wordsIn hAPP transgenic mice, NGF gene activity stayed unchanged with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeNGF mRNA levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein levels of other neurotrophic factors, including BDNF, NT3, NT4, and CNTF, were unchanged. mRNA levels of NGF and other neurotrophins were also unchanged.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In the hAPP transgenic model, other neurotrophin mRNA levels were unchanged with Cerebrolysin.

    In plain wordsIn hAPP transgenic mice, other neurotrophin gene activity stayed unchanged with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeOther neurotrophin mRNA levels
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein levels of other neurotrophic factors, including BDNF, NT3, NT4, and CNTF, were unchanged. mRNA levels of NGF and other neurotrophins were also unchanged.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In hAPP transgenic mice, Cerebrolysin preserved TrKA immunoreactivity per cell in the nucleus basalis.

    In plain wordsIn hAPP transgenic mice, TrKA staining per cell remained preserved with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableTrKA immunoreactivity per cell
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Analysis of neurotrophin receptors showed preservation of the levels of TrKA and p75(NTR) immunoreactivity per cell in the nucleus basalis.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In hAPP transgenic mice, Cerebrolysin preserved p75(NTR) immunoreactivity per cell in the nucleus basalis.

    In plain wordsIn hAPP transgenic mice, p75(NTR) staining per cell remained preserved with Cerebrolysin compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicablep75(NTR) immunoreactivity per cell
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Analysis of neurotrophin receptors showed preservation of the levels of TrKA and p75(NTR) immunoreactivity per cell in the nucleus basalis.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In hAPP transgenic mice, Cerebrolysin reduced cholinergic cell deficits in the nucleus basalis compared with saline.

    In plain wordsIn mice with an Alzheimer's disease model, Cerebrolysin reduced cholinergic cell deficits in the nucleus basalis compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCholinergic cell deficits
    Study

    mousen: not reported in source

    hAPP transgenic model of Alzheimer's disease
    Comparator
    Saline-treated hAPP transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cholinergic cells in the nucleus basalis were reduced in the saline-treated hAPP tg mice, and treatment with CBL reduced these cholinergic deficits.
    1 context sentence
    Summary · context
    We investigate the effects of CBL in the hAPP tg model of AD on levels of neurotrophic factors, including pro-nerve growth factor (NGF), NGF, brain-derived neurotrophic factor (BDNF), neurotropin (NT)-3, NT4, and ciliary neurotrophic factor (CNTF).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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