Dual ionic interaction system based on polyelectrolyte complex and ionic, injectable, and thermosensitive hydrogel for sustained release of human growth hormone.

Park MR, Seo BB, Song SC

Biomaterials11 Nov 2012Cited by 54 (Europe PMC)

PMID23149013DOI10.1016/j.biomaterials.2012.10.033PepBankPUB-23149013

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking HGH (somatotropin).

01AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics
In rats, PEC-loaded hydrogels extended the hGH release period.
In plain wordsIn rats, PEC-loaded hydrogels extended the growth hormone release period.
Peptide
HGH (somatotropin)
Outcome
IncreaseIn vivo release period
Study
ratn: not reported in source
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The PEC-loaded hydrogels suppressed the initial burst release of hGH and extended the release period in vitro and in vivo.
1 context sentence(design, population, supporting numbers)
Summary · context
In a pharmacokinetic study in rats, the PEC-loaded anionic hydrogel extended half-life 13-fold with similar area under the curve (AUC) compared to hGH solution.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-2314901301
02AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics
In rats, PEC-loaded hydrogels suppressed the initial burst release of hGH.
In plain wordsIn rats, PEC-loaded hydrogels reduced the initial rapid release of growth hormone.
Peptide
HGH (somatotropin)
Outcome
DecreaseInitial burst release in vivo
Study
ratn: not reported in source
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The PEC-loaded hydrogels suppressed the initial burst release of hGH and extended the release period in vitro and in vivo.
1 context sentence(design, population, supporting numbers)
Summary · context
In a pharmacokinetic study in rats, the PEC-loaded anionic hydrogel extended half-life 13-fold with similar area under the curve (AUC) compared to hGH solution.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-2314901302
03AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics
In rats, PEC-loaded anionic hydrogel extended hGH half-life 13-fold compared with hGH solution.
In plain wordsIn rats, PEC-loaded anionic hydrogel extended growth hormone half-life 13-fold compared with growth hormone solution.
Peptide
HGH (somatotropin)
Outcome
IncreaseHalf-life
Study
ratn: not reported in source
Comparator
hGH solution
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Half-life ratio
13 fold
hydrogel versus solution
Source sentences
Summary
In a pharmacokinetic study in rats, the PEC-loaded anionic hydrogel extended half-life 13-fold with similar area under the curve (AUC) compared to hGH solution.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-2314901303
04AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics
In rats, hGH in PEC-loaded anionic hydrogel had similar area under the curve to hGH solution.
In plain wordsIn rats, growth hormone in PEC-loaded anionic hydrogel had similar overall exposure to growth hormone solution.
Peptide
HGH (somatotropin)
Outcome
Direction not reportedArea under the curve
Study
ratn: not reported in source
Comparator
hGH solution
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In a pharmacokinetic study in rats, the PEC-loaded anionic hydrogel extended half-life 13-fold with similar area under the curve (AUC) compared to hGH solution.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-2314901304
05AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, a single hGH hydrogel injection increased growth rate more than daily hGH solution injections for 7 days.
In plain wordsIn hypophysectomized rats, one growth hormone hydrogel injection increased growth more than daily growth hormone solution injections for 7 days.
Peptide
HGH (somatotropin)
Outcome
IncreaseGrowth rate
Study
ratn: not reported in source
Hypophysectomized rats
Comparator
Daily injection of hGH solution for 7 days
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Furthermore, single injection of PEC-loaded anionic hydrogel showed a more increased growth rate than daily injection of hGH solution for 7 days in hypophysectomized rats, demonstrating its potential as an injectable, sustained delivery system that can release bioactive hGH.
1 context sentence(design, population, supporting numbers)
Summary · context
In a pharmacokinetic study in rats, the PEC-loaded anionic hydrogel extended half-life 13-fold with similar area under the curve (AUC) compared to hGH solution.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-2314901305

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

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