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Study · Randomized controlled trial · n = 69 · 2013

3 results

Intranasal oxytocin increases covert attention to positive social cues.

Domes G, Sibold M, Schulze L, Lischke A, Herpertz SC, Heinrichs M

Psychological medicine12 Nov 2012Cited by 99 (Europe PMC)

PMID23146328 (opens in a new tab)DOI10.1017/s0033291712002565 (opens in a new tab)PepBankPUB-23146328
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In 69 healthy men, a single intranasal oxytocin dose shifted attention toward happy faces shown for 100 ms.

    In plain wordsIn healthy men, one oxytocin spray dose shifted attention toward happy faces shown very briefly.

    Peptide
    Oxytocin
    Outcome
    IncreaseAttention shift toward happy faces at 100 ms
    Study

    n = 69

    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Reaction times (RTs) in the dot-probe paradigm revealed a pronounced shift of attention towards happy facial expressions presented for 100 ms after OT administration
    1 context sentence
    Summary · context
    We investigated whether a single intranasal dose of OT (24 IU) would modulate the allocation of attentional resources towards positive and negative facial expressions using a dot-probe paradigm in a sample of 69 healthy men.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In 69 healthy men, oxytocin had no effect on the dot-probe attention measure for faces shown for 500 ms.

    In plain wordsIn healthy men, oxytocin spray had no effect on attention to faces shown for longer.

    Peptide
    Oxytocin
    Outcome
    No significant changeAttention shift at 500 ms presentation
    Study

    n = 69

    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    whereas there were no OT-induced effects for longer presentation times (500 ms).
    1 context sentence
    Summary · context
    We investigated whether a single intranasal dose of OT (24 IU) would modulate the allocation of attentional resources towards positive and negative facial expressions using a dot-probe paradigm in a sample of 69 healthy men.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In 69 healthy men, oxytocin had no effect on gaze toward the facial target, so overt attention did not explain the result.

    In plain wordsIn healthy men, oxytocin spray did not change where they looked at the face.

    Peptide
    Oxytocin
    Outcome
    No significant changeOvert visual attention (gaze toward facial target)
    Study

    n = 69

    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The results could not be attributed to modulations of overt visual attention as no substance effects on gazes towards the facial target were observed.
    1 context sentence
    Summary · context
    We investigated whether a single intranasal dose of OT (24 IU) would modulate the allocation of attentional resources towards positive and negative facial expressions using a dot-probe paradigm in a sample of 69 healthy men.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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