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Study · Animal study (in vivo) · mouse · 2012

6 results

[Impact of thymosin-alpha1 on reproduction of herpes simplex virus in cell system and on course of acute experimental infection in mice].

Mamedov MK, Safarova SM, Dadasheva AE

Georgian medical news1 Oct 2012Cited by 1 (Europe PMC)

PMID23131988 (opens in a new tab)PepBankPUB-23131988
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice infected with herpes simplex virus, parenteral thymosin alpha‑1 reduced the percentage of mice that fell ill.

    In plain wordsIn mice infected with herpes simplex virus, thymosin alpha‑1 injections reduced the share of mice that fell ill.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMorbidity percent in HSV-infected mice
    Study

    mousen: not reported in source

    acute HSV infection
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated · parenteralAs given in this study (mouse).

    Source sentences

    Summary
    Besides it was demonstrated that Ta1 parenteral administration to mice infected with HSV leaded to reduce of mice morbidity percent and prolonged of their survival rate.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice infected with herpes simplex virus, parenteral thymosin alpha‑1 prolonged survival.

    In plain wordsIn mice infected with herpes simplex virus, thymosin alpha‑1 injections prolonged survival.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSurvival rate in HSV-infected mice
    Study

    mousen: not reported in source

    acute HSV infection
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated · parenteralAs given in this study (mouse).

    Source sentences

    Summary
    Besides it was demonstrated that Ta1 parenteral administration to mice infected with HSV leaded to reduce of mice morbidity percent and prolonged of their survival rate.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In animals with experimental herpes simplex virus infection, thymosin alpha‑1 suppressed infection development more than acyclovir.

    In plain wordsIn animals with experimental herpes simplex virus infection, thymosin alpha‑1 suppressed the infection more than acyclovir did.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSuppression of experimental viral infection versus acyclovir
    Study

    mousen: not reported in source

    acute HSV infection
    Comparator
    Acyclovir
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ta1 ability to depress experimental viral infection development was higher than same ability of acyclovir.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured cells inoculated with herpes simplex virus, thymosin alpha‑1 inhibited virus reproduction.

    In plain wordsIn lab tests with cells infected with herpes simplex virus, thymosin alpha‑1 inhibited virus reproduction.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseHSV reproduction in cells
    Study

    n: not reported in source

    cultivated cell system inoculated with HSV
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was demonstrated that administration of tymosin-alpha1 in cultivated in vitro cellular system had been inoculated with HSV provided inhibition of HSV reproduction and defense of cells of HSV cytopathogenic action.
  5. 05LabIn vitro (cells)Efficacy outcome

    In cultured cells inoculated with herpes simplex virus, thymosin alpha‑1 protected cells from the virus cytopathic action.

    In plain wordsIn lab tests with cells infected with herpes simplex virus, thymosin alpha‑1 protected cells from virus damage.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseProtection of cells from HSV cytopathic action
    Study

    n: not reported in source

    cultivated cell system inoculated with HSV
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was demonstrated that administration of tymosin-alpha1 in cultivated in vitro cellular system had been inoculated with HSV provided inhibition of HSV reproduction and defense of cells of HSV cytopathogenic action.
  6. 06LabIn vitro (cells)Efficacy outcome

    In cultured cells inoculated with herpes simplex virus, thymosin alpha‑1 inhibited virus reproduction about as well as human alpha-interferon.

    In plain wordsIn lab tests with cells infected with herpes simplex virus, thymosin alpha‑1 and human alpha-interferon inhibited the virus about equally.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeHSV reproduction inhibition versus human alpha-interferon
    Study

    n: not reported in source

    cultivated cell system inoculated with HSV
    Comparator
    Human alpha-interferon
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover Ta1 ability to inhibit HSV reproduction in cell was comparable with the same ability of human alpha-interferon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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