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Study · Randomized controlled trial · n = 62 · 2013

3 results

Oxytocin differentially modulates eye gaze to naturalistic social signals of happiness and anger.

Domes G, Steiner A, Porges SW, Heinrichs M

Psychoneuroendocrinology29 Oct 2012Cited by 111 (Europe PMC)

PMID23117026 (opens in a new tab)DOI10.1016/j.psyneuen.2012.10.002 (opens in a new tab)PepBankPUB-23117026
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In 62 healthy men, intranasal oxytocin increased eye gaze toward neutral facial expressions versus placebo.

    In plain wordsIn healthy men, oxytocin spray raised looking at the eyes of neutral faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseEye gaze toward the eyes of neutral faces
    Study

    n = 62

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In line with previous studies, OT increased eye gaze toward neutral facial expressions.
    1 context sentence
    Summary · context
    In a placebo-controlled, double-blind, between-subject design, we assessed the effects of intranasal OT administration (24 IU) in 62 healthy male volunteers on eye gaze toward the eyes of neutral, positive (happy) and negative (angry) facial expressions compared with placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In 62 healthy men, eye gaze remained increased under oxytocin when the face showed a happy expression.

    In plain wordsIn healthy men, oxytocin spray kept raising looking at the eyes of happy faces.

    Peptide
    Oxytocin
    Outcome
    IncreaseEye gaze toward the eyes of happy faces
    Study

    n = 62

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Moreover, under OT treatment, eye gaze remained increased when the face showed a happy facial expression
    1 context sentence
    Summary · context
    In a placebo-controlled, double-blind, between-subject design, we assessed the effects of intranasal OT administration (24 IU) in 62 healthy male volunteers on eye gaze toward the eyes of neutral, positive (happy) and negative (angry) facial expressions compared with placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In 62 healthy men, eye gaze decreased under oxytocin when the face displayed an angry expression.

    In plain wordsIn healthy men, oxytocin spray lowered looking at the eyes of angry faces.

    Peptide
    Oxytocin
    Outcome
    DecreaseEye gaze toward the eyes of angry faces
    Study

    n = 62

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    but in contrast decreased when the face displayed an angry expression.
    1 context sentence
    Summary · context
    In a placebo-controlled, double-blind, between-subject design, we assessed the effects of intranasal OT administration (24 IU) in 62 healthy male volunteers on eye gaze toward the eyes of neutral, positive (happy) and negative (angry) facial expressions compared with placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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