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Study · Animal study (in vivo) · rat · 2012

2 results

Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.

Blevins JE, Moralejo DH, Wolden-Hanson TH, Thatcher BS, Ho JM, Kaiyala KJ, Matsumoto K

American journal of physiology. Regulatory, integrative and comparative physiology31 Oct 2012Cited by 23 (Europe PMC)

PMID23115121 (opens in a new tab)PMCIDPMC3532586 (opens in a new tab)DOI10.1152/ajpregu.00393.2012 (opens in a new tab)PepBankPUB-23115121
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Cck1r-/- rats, MTII suppressed food intake more strongly than in controls after central and peripheral administration.

    In plain wordsIn rats lacking the CCK1 receptor, MTII lowered food intake more than in normal rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake suppression by MTII
    Study

    ratn: not reported in source

    Cck1r-/- Fischer 344 rats
    Comparator
    Cck1r+/+ rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · central and peripheralAs given in this study (rat).

    Source sentences

    Summary
    We found an enhanced effect of MTII in Cck1r(-/-) rats to suppress food intake and body weight following both central and peripheral administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Cck1r-/- rats, MTII suppressed body weight more strongly than in controls after central and peripheral administration.

    In plain wordsIn rats lacking the CCK1 receptor, MTII lowered body weight more than in normal rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight suppression by MTII
    Study

    ratn: not reported in source

    Cck1r-/- Fischer 344 rats
    Comparator
    Cck1r+/+ rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · central and peripheralAs given in this study (rat).

    Source sentences

    Summary
    We found an enhanced effect of MTII in Cck1r(-/-) rats to suppress food intake and body weight following both central and peripheral administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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