Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115.

Kolik LG, Gudasheva TA, Seredenin SB

Bulletin of experimental biology and medicine1 Oct 2012Cited by 1 (Europe PMC)

PMID23113301DOI10.1007/s10517-012-1842-1PepBankPUB-23113301

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In BALB/c mice, cholecystokinin-4 type 2 receptor activation abolished the antianxiety effect of GB‑115.
In plain wordsIn mice, activation of cholecystokinin-4 type 2 receptors abolished the anxiety reduction from GB‑115.
Peptide
GB-115
Outcome
DecreaseAntianxiety effect during receptor activation
Study
mousen: not reported in source
BALB/c mice with cholecystokinin-4 type 2 receptor activation
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
Activation of cholecystokinin-4 type 2 receptors abolished the antianxiety effect of GB-115 in BALB/c mice.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of dipeptide GB-115, a retroanalogue of cholecystokinin-4 with anxiolytic properties, on the behavior of outbred rats and BALB/c and C57Bl/6 mice induced by cholecystokinin-4 receptor agonists and yohimbine.
Report a problemFND-2311330101
02AnimalAnimal study (in vivo)Efficacy outcome
In C57Bl/6 mice, GB‑115 prevented cholecystokinin-4-induced anxiety.
In plain wordsIn mice, GB‑115 prevented anxiety caused by cholecystokinin-4.
Peptide
GB-115
Outcome
DecreaseCholecystokinin-4-induced anxiety
Study
mousen: not reported in source
C57Bl/6 mice with cholecystokinin-4-induced anxiety
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
This dipeptide prevented the development of cholecystokinin-4-induced anxiety in C57Bl/6 mice and outbred rats.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of dipeptide GB-115, a retroanalogue of cholecystokinin-4 with anxiolytic properties, on the behavior of outbred rats and BALB/c and C57Bl/6 mice induced by cholecystokinin-4 receptor agonists and yohimbine.
Report a problemFND-2311330102
03AnimalAnimal study (in vivo)Efficacy outcome
In outbred rats, GB‑115 prevented cholecystokinin-4-induced anxiety.
In plain wordsIn rats, GB‑115 prevented anxiety caused by cholecystokinin-4.
Peptide
GB-115
Outcome
DecreaseCholecystokinin-4-induced anxiety
Study
ratn: not reported in source
Outbred rats with cholecystokinin-4-induced anxiety
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
This dipeptide prevented the development of cholecystokinin-4-induced anxiety in C57Bl/6 mice and outbred rats.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of dipeptide GB-115, a retroanalogue of cholecystokinin-4 with anxiolytic properties, on the behavior of outbred rats and BALB/c and C57Bl/6 mice induced by cholecystokinin-4 receptor agonists and yohimbine.
Report a problemFND-2311330103
04AnimalAnimal study (in vivo)Mechanism
In BALB/c mice, yohimbine did not modulate the effects of GB‑115.
In plain wordsIn mice, yohimbine did not change the effects of GB‑115.
Peptide
GB-115
Outcome
No significant changeGB-115 effects with yohimbine
Study
mousen: not reported in source
BALB/c mice treated with yohimbine
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
α(2)-Adrenoceptor antagonist yohimbine did not modulate the effects of GB-115 in BALB/c mice.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of dipeptide GB-115, a retroanalogue of cholecystokinin-4 with anxiolytic properties, on the behavior of outbred rats and BALB/c and C57Bl/6 mice induced by cholecystokinin-4 receptor agonists and yohimbine.
Report a problemFND-2311330104
05AnimalAnimal study (in vivo)Efficacy outcome
In C57Bl/6 mice, GB‑115 did not prevent yohimbine-induced anxiety.
In plain wordsIn mice, GB‑115 did not prevent anxiety caused by yohimbine.
Peptide
GB-115
Outcome
No significant changeYohimbine-induced anxiety
Study
mousen: not reported in source
C57Bl/6 mice with yohimbine-induced anxiety
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
GB-115 did not prevent the development of yohimbine-induced anxiety in C57Bl/6 mice.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of dipeptide GB-115, a retroanalogue of cholecystokinin-4 with anxiolytic properties, on the behavior of outbred rats and BALB/c and C57Bl/6 mice induced by cholecystokinin-4 receptor agonists and yohimbine.
Report a problemFND-2311330105

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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