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Study · Observational study · n = 71 · 2013

2 results

The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: a comparison.

Kinoshita Y, Tominaga A, Usui S, Arita K, Sakoguchi T, Sugiyama K, Kurisu K

Endocrine journal19 Oct 2012Cited by 12 (Europe PMC)

PMID23079545 (opens in a new tab)DOI10.1507/endocrj.ej12-0230 (opens in a new tab)PepBankPUB-23079545
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanObservational studyActivity measurement

    In 71 adults with pituitary tumors, the peak GH response to the GHRP‑2 test (median 28.88 μg/L) was higher than to the insulin tolerance test (median 9.38 μg/L).

    In plain wordsIn adults with pituitary tumors, the GHRP‑2 test produced a higher peak growth hormone response than the insulin tolerance test.

    Peptide
    GHRP-2
    Outcome
    IncreasePeak GH response to GHRP-2 test versus ITT
    Study

    n = 71

    Comparator
    Insulin tolerance test (ITT)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Peak GH response
    28.88 μg/L
    GHRP-2 test, median
    Peak GH response
    9.38 μg/L
    ITT, median

    Source sentences

    Summary
    The peak GH responses were significantly lower with the ARG test (median 4.43 μg/L) (p < 0.0001) than with the ITT (median 9.38 μg/L), and the peak GH responses with the GHRP-2 test (median 28.88 μg/L) were higher (p < 0.0001).
    1 context sentence
    Summary · context
    Three stimulation tests (ITT, arginine test, and GHRP-2 test) were conducted in 71 pre-operative adult patients with pituitary tumors (age, 18-65 years).
  2. 02HumanObservational studyActivity measurement

    Compared with the insulin tolerance test, the GHRP‑2 test had a sensitivity of 81.3% and a specificity of 94.5% for diagnosing severe adult GH deficiency.

    In plain wordsCompared with the insulin tolerance test, the GHRP‑2 test picked up 81.3% of severe GH deficiency cases and correctly cleared 94.5% of the others.

    Peptide
    GHRP-2
    Outcome
    Not applicableSensitivity and specificity of GHRP-2 test for severe AGHD
    Study

    n = 71

    Comparator
    Insulin tolerance test (ITT)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Sensitivity
    81.3%
    GHRP-2 test vs ITT
    Specificity
    94.5%
    GHRP-2 test vs ITT

    Source sentences

    Summary
    The sensitivities and specificities of the ARG / GHRP-2 tests compared to the ITT for the diagnosis of severe AGHD (peak GH responses to ITT ≤ 1.8 μg/L) were 93.8% / 81.3% and 85.5% / 94.5%, respectively.
    1 context sentence
    Summary · context
    Three stimulation tests (ITT, arginine test, and GHRP-2 test) were conducted in 71 pre-operative adult patients with pituitary tumors (age, 18-65 years).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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