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Study · Not a test of the peptide alone · 2013

2 results

Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared α2-adrenoceptor in the brain-gut axis of rats in the forced swimming test.

Xie Y, Huang X, Hu SY, Qiu XJ, Zhang YJ, Ren P, Wang Y, Ji H, Zhang CH, Xie WB, He J, Xie MZ, Huang HY, Liu ZQ, Zhou HH

Neuropharmacology10 Oct 2012Cited by 24 (Europe PMC)

PMID23063894 (opens in a new tab)DOI10.1016/j.neuropharm.2012.10.003 (opens in a new tab)PepBankPUB-23063894
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats subjected to forced swimming, GHRP‑6 enhanced the rise in plasma ghrelin induced by meranzin hydrate.

    In plain wordsIn rats, GHRP‑6 enhanced the rise in plasma ghrelin caused by meranzin hydrate.

    Peptide
    GHRP-6
    Outcome
    IncreasePlasma ghrelin
    Study

    ratn: not reported in source

    Comparator
    Meranzin hydrate without GHRP-6 in rats subjected to forced swimming
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    MH (9 mg/kg) increased plasma ghrelin levels in rats subjected to the FST; this increase was enhanced by the ghrelin receptor agonist, GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat jejunum, GHRP‑6 partly reversed yohimbine inhibition of meranzin hydrate-induced contractions.

    In plain wordsIn lab tests with rat intestine, GHRP‑6 partly reversed yohimbine inhibition of contractions induced by meranzin hydrate.

    Peptide
    GHRP-6
    Outcome
    IncreaseJejunal contractions
    Study

    ratn: not reported in source

    Jejunum from rats subjected to forced swimming
    Comparator
    Meranzin hydrate plus yohimbine without GHRP-6
    Outcome group
    Gastrointestinal motility · Gastrointestinal

    Source sentences

    Summary
    Furthermore, the inhibitory effect of yohimbine was partly reversed by the ghrelin receptor agonist, GHRP-6.
    1 context sentence
    Summary · context
    In vitro, MH (10 μM) increased jejunal contractions in rats subjected to the FST; this effect was inhibited by yohimbine.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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