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Study · Animal study (in vivo) · mouse · 2012

6 results

[Effects of nootropic drugs on behavior of BALB/c and C57BL/6 mice in the exploratory cross-maze test].

Vasil'eva EV, Salimov RM, Kovalev GI

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2012

PMID23025044 (opens in a new tab)PepBankPUB-23025044
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, subchronic treatment with semax and the other tested nootropic drugs improved exploratory behavior in the cross-maze test.

    In plain wordsIn BALB/c mice, semax improved exploring behavior in a maze test. The other tested drugs did too.

    Peptide
    Semax
    Outcome
    IncreaseExploratory behavior in BALB/c mice
    Study

    mousen: not reported in source

    Exploratory cross-maze test, BALB/c and C57BL/6
    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subchronicAs given in this study (mouse).

    Source sentences

    Summary
    All tested drugs clearly improved the exploratory behavior in BALB/c mice only.
    1 context sentence
    Summary · context
    Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice, the tested nootropic drugs, semax included, did not improve exploratory behavior, which improved in BALB/c mice only.

    In plain wordsIn C57BL/6 mice, semax and the other drugs did not improve exploring behavior. Only BALB/c mice improved.

    Peptide
    Semax
    Outcome
    No significant changeExploratory behavior in C57BL/6 mice
    Study

    mousen: not reported in source

    Exploratory cross-maze test, BALB/c and C57BL/6
    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subchronicAs given in this study (mouse).

    Source sentences

    Summary
    All tested drugs clearly improved the exploratory behavior in BALB/c mice only.
    1 context sentence
    Summary · context
    Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, semax reduced anxiety in the cross-maze test.

    In plain wordsIn BALB/c mice, semax lowered anxiety-like behavior in a maze test.

    Peptide
    Semax
    Outcome
    DecreaseAnxiety in BALB/c mice
    Study

    mousen: not reported in source

    Exploratory cross-maze test, BALB/c and C57BL/6
    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · subchronicAs given in this study (mouse).

    Source sentences

    Summary
    In BALB/c mice, piracetam, phenotropil, noopept, and semax also reduced anxiety, while phenotropil additionally increased locomotor activity.
    1 context sentence
    Summary · context
    Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, noopept reduced anxiety compared with placebo.

    In plain wordsIn BALB/c mice, noopept reduced anxiety compared with placebo.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseAnxiety
    Study

    mousen: not reported in source

    BALB/c mice
    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · subchronicAs given in this study (mouse).

    Source sentences

    Summary
    In BALB/c mice, piracetam, phenotropil, noopept, and semax also reduced anxiety, while phenotropil additionally increased locomotor activity.
    1 context sentence
    Summary · context
    Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test.

Studies that did not test the peptide alone2

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

  1. 05AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, all tested nootropic drugs, including noopept, improved exploratory behavior compared with placebo.

    In plain wordsIn BALB/c mice, all tested nootropic drugs, including noopept, improved exploratory behavior compared with placebo.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseExploratory behavior
    Study

    mousen: not reported in source

    BALB/c mice
    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    All tested drugs clearly improved the exploratory behavior in BALB/c mice only.
    1 context sentence
    Summary · context
    Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  2. 06AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice, the tested nootropic drugs, including noopept, did not show the exploratory improvement reported only in BALB/c mice.

    In plain wordsIn C57BL/6 mice, the tested drugs, including noopept, did not show the exploratory improvement reported only in BALB/c mice.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedExploratory behavior in C57BL/6 mice
    Study

    mousen: not reported in source

    C57BL/6 mice
    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    All tested drugs clearly improved the exploratory behavior in BALB/c mice only.
    1 context sentence
    Summary · context
    Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 12Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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