In adult rats, MTII injected into the ventral tegmental area dose-dependently inhibited feeding for up to 24 hours.
In plain wordsIn rats, MTII injected into a brain area called the VTA reduced eating, with larger doses having larger effects, for up to 24 hours.
- Peptide
- Melanotan II
- Outcome
- DecreaseFeeding after VTA injection
- Study
ratn: not reported in source
Adult rats- Outcome group
- Appetite and food intake · Metabolic and weight
- Studied dose
- Dose not stated · injection into the ventral tegmental areaAs given in this study (rat).
Source sentences
Injection of MTII into the VTA dose-dependently inhibited feeding for up to 24 h, while injection of SHU9119 into the VTA dose-dependently stimulated feeding for up to 24 h.
1 context sentence(design, population, supporting numbers)
These studies tested whether injection of melanocortin receptor agonists and antagonists directly into the ventral tegmental area (VTA) of adult rats affects feeding and body weight.