Experimental study of antinociceptive potency of dipeptide GB-115 during chemical and thermal stimulation.

Kolik LG, Zhukov VN, Gudasheva TA, Seredenin SB

Bulletin of experimental biology and medicine1 Aug 2012Cited by 1 (Europe PMC)

PMID22977846DOI10.1007/s10517-012-1742-4PepBankPUB-22977846

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, peroral GB‑115 decreased acetic acid-induced abdominal contractions.
In plain wordsIn mice, oral GB‑115 reduced abdominal contractions caused by acetic acid.
Peptide
GB-115
Outcome
DecreaseAcetic acid-induced abdominal contractions
Study
mousen: not reported in source
Acetic acid-induced nociception
Outcome group
Pain · Nervous system and cognition
Studied dose
0.1-20 mg/kg · peroralAs given in this study (mouse).
Source sentences
Summary
Peroral administration of GB-115 (0.1-20 mg/kg) decreased the incidence of abdominal contractions induced with intraperitoneal acetic acid (0.75%).
1 context sentence(design, population, supporting numbers)
Summary · context
The study examined the antinociceptive potency of dipeptide compound GB-115 (amide N-6-phenylhexanoyl-glycyl-L-tryptophan) during thermal and chemical noxious stimulation of mice.
Report a problemFND-2297784601
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, the antinociceptive effect of GB‑115 was comparable to sodium diclofenac.
In plain wordsIn mice, GB‑115 had an antinociceptive effect comparable to sodium diclofenac.
Peptide
GB-115
Outcome
Direction not reportedAntinociceptive effect versus diclofenac
Study
mousen: not reported in source
Chemical noxious stimulation
Comparator
Sodium diclofenac 20 mg/kg
Outcome group
Pain · Nervous system and cognition
Studied dose
0.1-20 mg/kg · peroralAs given in this study (mouse).
Source sentences
Summary
This effect was comparable to that of sodium diclofenac (20 mg/kg)
2 context sentences(design, population, supporting numbers)
Summary · context
Peroral administration of GB-115 (0.1-20 mg/kg) decreased the incidence of abdominal contractions induced with intraperitoneal acetic acid (0.75%).
Summary · context
The study examined the antinociceptive potency of dipeptide compound GB-115 (amide N-6-phenylhexanoyl-glycyl-L-tryptophan) during thermal and chemical noxious stimulation of mice.
Report a problemFND-2297784602
03AnimalAnimal study (in vivo)Mechanism
In mice, naloxone only partially antagonized the analgesic effect of GB‑115.
In plain wordsIn mice, naloxone only partly blocked the pain response reduction from GB‑115.
Peptide
GB-115
Outcome
DecreaseNaloxone antagonism of analgesia
Study
mousen: not reported in source
Chemical noxious stimulation
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
it was only partially antagonized with naloxone indicating the presence of significant non-opioid component in analgesic effect of GB-115.
1 context sentence(design, population, supporting numbers)
Summary · context
The study examined the antinociceptive potency of dipeptide compound GB-115 (amide N-6-phenylhexanoyl-glycyl-L-tryptophan) during thermal and chemical noxious stimulation of mice.
Report a problemFND-2297784603
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, GB‑115 moderated the tail flick nociceptive response under non-selective opioid receptor blockade with naloxone.
In plain wordsIn mice, GB‑115 reduced the tail flick pain response during opioid receptor blockade with naloxone.
Peptide
GB-115
Outcome
DecreaseTail flick nociceptive response under opioid blockade
Study
mousen: not reported in source
Tail flick test with naloxone
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Ability of this dipeptide to moderate the nociceptive response in tail flick test under a non-selective blockade of the opioid receptors with naloxone
1 context sentence(design, population, supporting numbers)
Summary · context
The study examined the antinociceptive potency of dipeptide compound GB-115 (amide N-6-phenylhexanoyl-glycyl-L-tryptophan) during thermal and chemical noxious stimulation of mice.
Report a problemFND-2297784604
05AnimalAnimal study (in vivo)Efficacy outcome
In mice, GB‑115 lacked similar analgesic potency in the hot plate test.
In plain wordsIn mice, GB‑115 did not show similar pain response reduction in the hot plate test.
Peptide
GB-115
Outcome
Direction not reportedHot plate analgesic potency
Study
mousen: not reported in source
Hot plate test
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
the absence of similar analgesic potency assessed in the hot plate test
1 context sentence(design, population, supporting numbers)
Summary · context
The study examined the antinociceptive potency of dipeptide compound GB-115 (amide N-6-phenylhexanoyl-glycyl-L-tryptophan) during thermal and chemical noxious stimulation of mice.
Report a problemFND-2297784605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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