Synthesis, characterization, and biocompatibility of a novel biomimetic material based on MGF-Ct24E modified poly(D, L-lactic acid).

Li Y, Zhang B, Ruan C, Wang P, Sun J, Pan J, Wang Y

Journal of biomedical materials research. Part A31 Aug 2012Cited by 7 (Europe PMC)

PMID22941771DOI10.1002/jbm.a.34276PepBankPUB-22941771

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

01LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
Introducing MGF-Ct24E into the polymer film improved osteoblast proliferation in vitro.
In plain wordsIn cells, osteoblasts grew more on films that carried the peptide than on the plain polymer films.
Peptide
MGF / PEG-MGF
Outcome
IncreaseOsteoblast proliferation on MGF-Ct24E-MPLA films
Study
n: not reported in source
Osteoblasts on MGF-Ct24E-MPLA films
Comparator
PDLLA and MPLA films
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
the results indicated that the introduction of MGF-Ct24E could improve osteoblasts proliferation
1 context sentence(design, population, supporting numbers)
Summary · context
MGF-Ct24Es were grafted into the side chain of MPLA via a stable covalent amide bond using 1-ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide as the condensing agent to produce biomimetic MPLA materials (MGF-Ct24E-MPLA).
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2294177103
02LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
Introducing MGF-Ct24E into the polymer film improved osteoblast mineralization in vitro.
In plain wordsIn cells, osteoblasts formed more mineral on films that carried the peptide than on the plain polymer films.
Peptide
MGF / PEG-MGF
Outcome
IncreaseOsteoblast mineralization on MGF-Ct24E-MPLA films
Study
n: not reported in source
Osteoblasts on MGF-Ct24E-MPLA films
Comparator
PDLLA and MPLA films
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
the results indicated that the introduction of MGF-Ct24E could improve osteoblasts proliferation, mineralization
1 context sentence(design, population, supporting numbers)
Summary · context
MGF-Ct24Es were grafted into the side chain of MPLA via a stable covalent amide bond using 1-ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide as the condensing agent to produce biomimetic MPLA materials (MGF-Ct24E-MPLA).
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2294177104
03LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
Introducing MGF-Ct24E into the polymer film delayed osteoblast differentiation in vitro.
In plain wordsIn cells, osteoblasts matured later on films that carried the peptide than on the plain polymer films.
Peptide
MGF / PEG-MGF
Outcome
DecreaseOsteoblast differentiation on MGF-Ct24E-MPLA films
Study
n: not reported in source
Osteoblasts on MGF-Ct24E-MPLA films
Comparator
PDLLA and MPLA films
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
the results indicated that the introduction of MGF-Ct24E could improve osteoblasts proliferation, mineralization, and delay differentiation
1 context sentence(design, population, supporting numbers)
Summary · context
MGF-Ct24Es were grafted into the side chain of MPLA via a stable covalent amide bond using 1-ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide as the condensing agent to produce biomimetic MPLA materials (MGF-Ct24E-MPLA).
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2294177105
04LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Other
MGF-Ct24E was grafted onto the polymer MPLA with a grafting efficiency of about 29.9%.
In plain wordsIn lab tests, about 29.9% of the MGF-Ct24E peptide attached to the polymer material.
Peptide
MGF / PEG-MGF
Outcome
Not applicableGrafting efficiency of MGF-Ct24E
Study
n: not reported in source
Outcome group
Peptide structure and chemistry · Pharmacology
Measurements
Grafting efficiency
≈ 29.9%
MGF-Ct24E on MPLA
Source sentences
Summary
Data revealed that the grafting efficiency of MGF-Ct24E was about 29.9%.
1 context sentence(design, population, supporting numbers)
Summary · context
MGF-Ct24Es were grafted into the side chain of MPLA via a stable covalent amide bond using 1-ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide as the condensing agent to produce biomimetic MPLA materials (MGF-Ct24E-MPLA).
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2294177101
05LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Other
The polymer grafted with MGF-Ct24E (MGF-Ct24E-MPLA) had better hydrophilicity than PDLLA and MPLA.
In plain wordsIn lab tests, the material carrying the peptide absorbed water better than the two plain polymers.
Peptide
MGF / PEG-MGF
Outcome
IncreaseHydrophilicity of MGF-Ct24E-MPLA
Study
n: not reported in source
Comparator
PDLLA and MPLA
Outcome group
Peptide structure and chemistry · Pharmacology
Source sentences
Summary
MGF-Ct24E-MPLA had better hydrophilicity than PDLLA and MPLA.
1 context sentence(design, population, supporting numbers)
Summary · context
MGF-Ct24Es were grafted into the side chain of MPLA via a stable covalent amide bond using 1-ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide as the condensing agent to produce biomimetic MPLA materials (MGF-Ct24E-MPLA).
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2294177102

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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