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Study · Randomized controlled trial · n = 102 · 2013

3 results

Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.

Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychoneuroendocrinology17 Aug 2012Cited by 45 (Europe PMC)

PMID22902063 (opens in a new tab)DOI10.1016/j.psyneuen.2012.06.016 (opens in a new tab)PepBankPUB-22902063
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In 102 participants, intranasal oxytocin had no main effect on inhibition of task-irrelevant emotional faces versus placebo.

    In plain wordsIn 102 people, oxytocin spray did not change overall ability to ignore emotional faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeInhibition of emotional faces, main effect of drug
    Study

    n = 102

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Although no main effect of drug administration on inhibition was observed
    1 context sentence
    Summary · context
    In a randomized placebo-controlled study, we examined the influence of intranasal oxytocin and placebo on the interference control component of inhibition (i.e. ability to ignore task-irrelevant information) in 102 participants using a negative affective priming task with sad, angry, and happy faces.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In participants with high depression scores, intranasal oxytocin impaired inhibition of sad faces relative to placebo (drug x depressive symptom interaction).

    In plain wordsIn people with high depression scores, oxytocin spray made it harder to ignore sad faces than placebo did.

    Peptide
    Oxytocin
    Outcome
    DecreaseInhibition of sad faces by depression score
    Study

    n = 102

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Although no main effect of drug administration on inhibition was observed, a drug × depressive symptom interaction (β = -0.25; t = -2.6, p < 0.05) predicted the inhibition of sad faces. Relative to placebo, participants with high depression scores who were administered oxytocin were unable to inhibi…
    1 context sentence
    Summary · context
    In a randomized placebo-controlled study, we examined the influence of intranasal oxytocin and placebo on the interference control component of inhibition (i.e. ability to ignore task-irrelevant information) in 102 participants using a negative affective priming task with sad, angry, and happy faces.
  3. 03HumanRandomized controlled trialEfficacy outcome

    Among participants with low depression scores, intranasal oxytocin was not related to inhibition of sad faces.

    In plain wordsIn people with low depression scores, oxytocin spray did not change how well they ignored sad faces.

    Peptide
    Oxytocin
    Outcome
    No significant changeInhibition of sad faces in participants with low depression scores
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    There was no relationship between drug administration and inhibition among those with low depression scores.
    1 context sentence
    Summary · context
    In a randomized placebo-controlled study, we examined the influence of intranasal oxytocin and placebo on the interference control component of inhibition (i.e. ability to ignore task-irrelevant information) in 102 participants using a negative affective priming task with sad, angry, and happy faces.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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